|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A6 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
1396.0
cpm
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A5 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
341.0
cpm
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A4 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
927.0
cpm
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
1377.0
cpm
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
2483.0
cpm
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
46.0
cpm
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A6 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
27.0
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A5 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
7.0
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A4 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
18.0
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
27.0
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
49.0
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control
|
Glycine max
|
1.0
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HNE-dG adducts using [32P]labeling based autoradiography (Rvb = 34 cpm)
|
Glycine max
|
1679.0
cpm
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HX-dG adducts using [32P]labeling based autoradiography
|
Glycine max
|
1823.0
cpm
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HNE-dG adducts measured per 10'9 nucleotides using [32P]labeling based autoradiography (Rvb = 2 no unit)
|
Glycine max
|
33.0
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HX-dG adducts measured per 10'9 nucleotides using [32P]labeling based autoradiography
|
Glycine max
|
47.0
|
|
Journal : J Agric Food Chem
Title : DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
Year : 2008
Volume : 56
Issue : 15
First Page : 6751
Last Page : 6760
Authors : Boerth DW, Eder E, Stanks JR, Wanek P, Wacker M, Gaulitz S, Skypeck D, Pandolfo D, Yashin M.
Abstract : Plant studies have been carried out to identify the nature and extent of the formation of adducts with DNA bases when treated with pesticide formulations. DNA extracted from crop plants after treatment with pesticide formulations has yielded evidence of adduct formation. The extent of DNA modification has been established by (32)P postlabeling studies. The radiochromatograms from (32)P postlabeling of isolated plant DNA from grapes, bush beans, soybeans, pumpkins, and cucumbers show elevated adduct levels in treated vegetable plants as compared with untreated controls. A number of different adduct spots appear, likely indicating adduct formation with pesticide molecules or their metabolites. The DNA adducts from hexenal and 4-hydroxy-2-nonenal were clearly observed, indicating oxidative stress and lipid peroxidation in the plant.
|
Dissociation constant, pKa of the compound at pH 7.3
|
None
|
0.0
|
|
Journal : J Agric Food Chem
Title : Importance of physicochemical properties for the design of new pesticides.
Year : 2011
Volume : 59
Issue : 7
First Page : 2909
Last Page : 2917
Authors : Akamatsu M.
Abstract : The physicochemical properties of candidate compounds play important roles in the design of new pesticides. Pesticides must be absorbed by pests, be transported to the target site, and then interact with proteins. Hydrophobicity is very important for these processes. Log P, where P is the partition coefficient in the 1-octanol/water system, is commonly used as a hydrophobic descriptor and correlates with membrane permeation and transport. It was recently reported that permeability by the parallel artificial membrane permeation assay (PAMPA) could be used to predict human oral absorption of passively transported compounds. PAMPA, which is a rapid high-throughput screening system, may be useful to predict pesticide absorption because PAMPA permeability can be calculated using log P and other parameters. Electronic and structural properties as well as hydrophobicity are important factors for protein-ligand interaction. To show the importance of physicochemical properties, the classic QSAR and CoMFA of neonicotinoids and prediction of bioavailability of pesticides in terms of membrane permeability in comparison with drugs are described.
|
Apparent hydrophobicity, log D of the compound in Octanol-buffer
|
None
|
3.3
|
|
Journal : J Agric Food Chem
Title : Importance of physicochemical properties for the design of new pesticides.
Year : 2011
Volume : 59
Issue : 7
First Page : 2909
Last Page : 2917
Authors : Akamatsu M.
Abstract : The physicochemical properties of candidate compounds play important roles in the design of new pesticides. Pesticides must be absorbed by pests, be transported to the target site, and then interact with proteins. Hydrophobicity is very important for these processes. Log P, where P is the partition coefficient in the 1-octanol/water system, is commonly used as a hydrophobic descriptor and correlates with membrane permeation and transport. It was recently reported that permeability by the parallel artificial membrane permeation assay (PAMPA) could be used to predict human oral absorption of passively transported compounds. PAMPA, which is a rapid high-throughput screening system, may be useful to predict pesticide absorption because PAMPA permeability can be calculated using log P and other parameters. Electronic and structural properties as well as hydrophobicity are important factors for protein-ligand interaction. To show the importance of physicochemical properties, the classic QSAR and CoMFA of neonicotinoids and prediction of bioavailability of pesticides in terms of membrane permeability in comparison with drugs are described.
|
Apparent permeability of the compound by PAMPA
|
None
|
-5.28
|
|
Journal : J Agric Food Chem
Title : Importance of physicochemical properties for the design of new pesticides.
Year : 2011
Volume : 59
Issue : 7
First Page : 2909
Last Page : 2917
Authors : Akamatsu M.
Abstract : The physicochemical properties of candidate compounds play important roles in the design of new pesticides. Pesticides must be absorbed by pests, be transported to the target site, and then interact with proteins. Hydrophobicity is very important for these processes. Log P, where P is the partition coefficient in the 1-octanol/water system, is commonly used as a hydrophobic descriptor and correlates with membrane permeation and transport. It was recently reported that permeability by the parallel artificial membrane permeation assay (PAMPA) could be used to predict human oral absorption of passively transported compounds. PAMPA, which is a rapid high-throughput screening system, may be useful to predict pesticide absorption because PAMPA permeability can be calculated using log P and other parameters. Electronic and structural properties as well as hydrophobicity are important factors for protein-ligand interaction. To show the importance of physicochemical properties, the classic QSAR and CoMFA of neonicotinoids and prediction of bioavailability of pesticides in terms of membrane permeability in comparison with drugs are described.
|
Hydrophobicity, log P of the compound in octanol-water by shaking-flask method
|
None
|
3.3
|
|
Journal : J Agric Food Chem
Title : Importance of physicochemical properties for the design of new pesticides.
Year : 2011
Volume : 59
Issue : 7
First Page : 2909
Last Page : 2917
Authors : Akamatsu M.
Abstract : The physicochemical properties of candidate compounds play important roles in the design of new pesticides. Pesticides must be absorbed by pests, be transported to the target site, and then interact with proteins. Hydrophobicity is very important for these processes. Log P, where P is the partition coefficient in the 1-octanol/water system, is commonly used as a hydrophobic descriptor and correlates with membrane permeation and transport. It was recently reported that permeability by the parallel artificial membrane permeation assay (PAMPA) could be used to predict human oral absorption of passively transported compounds. PAMPA, which is a rapid high-throughput screening system, may be useful to predict pesticide absorption because PAMPA permeability can be calculated using log P and other parameters. Electronic and structural properties as well as hydrophobicity are important factors for protein-ligand interaction. To show the importance of physicochemical properties, the classic QSAR and CoMFA of neonicotinoids and prediction of bioavailability of pesticides in terms of membrane permeability in comparison with drugs are described.
|
Insecticidal activity against Lepidoptera infected rice plant assessed as increase in grain yield at 0.75 kg ai/ha applied as emulsified concentrates through foliar spray on 30 to 50 days post planting (Rvb = 28%)
|
Lepidoptera
|
42.0
%
|
|
Journal : Crop Protection
Year : 2006
Volume : 25
Issue : 5
First Page : 409
Last Page : 417
|
Insecticidal activity against Lepidoptera infected rice plant assessed as white earhead damage at 0.75 kg ai/ha applied as emulsified concentrates through foliar spray on 30 to 50 days post planting (Rvb = 12.17%)
|
Lepidoptera
|
3.19
%
|
|
Journal : Crop Protection
Year : 2006
Volume : 25
Issue : 5
First Page : 409
Last Page : 417
|
Insecticidal activity against Lepidoptera infected rice plant assessed as dead heart damage at 0.75 kg ai/ha applied as emulsified concentrates through foliar spray on 30 to 50 days post planting (Rvb = 11.87%)
|
Lepidoptera
|
8.14
%
|
|
Journal : Crop Protection
Year : 2006
Volume : 25
Issue : 5
First Page : 409
Last Page : 417
|
Ratio of EC50 for Daphnia magna to EC50 for first instar larvae of Cheumatopsyche brevilineata
|
None
|
-0.31
|
|
Journal : J Pesticide Sci
Title : A useful new insecticide bioassay using first-instar larvae of a net-spinning caddisfly, Cheumatopsyche brevilineata (Trichoptera: Hydropsychidae)
Year : 2009
Volume : 34
Issue : 1
First Page : 13
Last Page : 20
Authors : Yokoyama A, Ohtsu K, Iwafune T, Nagai T, Ishihara S, Kobara Y, Horio T, Endo S
|
Insecticidal activity against first-instar larvae of Cheumatopsyche brevilineata after 48 hr
|
Cheumatopsyche
|
0.00177
ug.mL-1
|
|
Journal : J Pesticide Sci
Title : A useful new insecticide bioassay using first-instar larvae of a net-spinning caddisfly, Cheumatopsyche brevilineata (Trichoptera: Hydropsychidae)
Year : 2009
Volume : 34
Issue : 1
First Page : 13
Last Page : 20
Authors : Yokoyama A, Ohtsu K, Iwafune T, Nagai T, Ishihara S, Kobara Y, Horio T, Endo S
|
Octanol-water partition coefficient, log KOW of the compound
|
None
|
3.3
|
|
Journal : J Pesticide Sci
Title : A useful new insecticide bioassay using first-instar larvae of a net-spinning caddisfly, Cheumatopsyche brevilineata (Trichoptera: Hydropsychidae)
Year : 2009
Volume : 34
Issue : 1
First Page : 13
Last Page : 20
Authors : Yokoyama A, Ohtsu K, Iwafune T, Nagai T, Ishihara S, Kobara Y, Horio T, Endo S
|
Insecticidal activity against Daphnia magna after 48 hr
|
Daphnia magna
|
0.00087
ug.mL-1
|
|
Journal : J Pesticide Sci
Title : A useful new insecticide bioassay using first-instar larvae of a net-spinning caddisfly, Cheumatopsyche brevilineata (Trichoptera: Hydropsychidae)
Year : 2009
Volume : 34
Issue : 1
First Page : 13
Last Page : 20
Authors : Yokoyama A, Ohtsu K, Iwafune T, Nagai T, Ishihara S, Kobara Y, Horio T, Endo S
|
Ratio of LD50 for Laodelphax striatella Ibaraki (small brown planthopper) to LD50 for susceptible Laodelphax striatella
|
Laodelphax striatella
|
3.3
|
|
Journal : J Pesticide Sci
Title : Insecticide Resistance and Insensitive Acetylcholinesterase in Small Brown Planthopper, Laodelphax striatellus
Year : 2000
Volume : 25
Issue : 4
First Page : 395
Last Page : 397
Authors : ENDO S, TSURUMACHI M
|
Ratio of LD50 for Laodelphax striatella Kumamoto (small brown planthopper) to LD50 for susceptible Laodelphax striatella
|
Laodelphax striatella
|
8.7
|
|
Journal : J Pesticide Sci
Title : Insecticide Resistance and Insensitive Acetylcholinesterase in Small Brown Planthopper, Laodelphax striatellus
Year : 2000
Volume : 25
Issue : 4
First Page : 395
Last Page : 397
Authors : ENDO S, TSURUMACHI M
|
Insecticidal activity against Laodelphax striatella Ibaraki (small brown planthopper) assessed as mortality compound treated topically on dorsal side
|
Laodelphax striatella
|
28.0
mg.kg-1
|
|
Journal : J Pesticide Sci
Title : Insecticide Resistance and Insensitive Acetylcholinesterase in Small Brown Planthopper, Laodelphax striatellus
Year : 2000
Volume : 25
Issue : 4
First Page : 395
Last Page : 397
Authors : ENDO S, TSURUMACHI M
|
Insecticidal activity against Laodelphax striatella Kumamoto (small brown planthopper) assessed as mortality compound treated topically on dorsal side
|
Laodelphax striatella
|
74.0
mg.kg-1
|
|
Journal : J Pesticide Sci
Title : Insecticide Resistance and Insensitive Acetylcholinesterase in Small Brown Planthopper, Laodelphax striatellus
Year : 2000
Volume : 25
Issue : 4
First Page : 395
Last Page : 397
Authors : ENDO S, TSURUMACHI M
|
Insecticidal activity against susceptible Laodelphax striatella (small brown planthopper) assessed as mortality compound treated topically on dorsal side
|
Laodelphax striatella
|
8.5
mg.kg-1
|
|
Journal : J Pesticide Sci
Title : Insecticide Resistance and Insensitive Acetylcholinesterase in Small Brown Planthopper, Laodelphax striatellus
Year : 2000
Volume : 25
Issue : 4
First Page : 395
Last Page : 397
Authors : ENDO S, TSURUMACHI M
|
Insecticidal activity against Drosophila suzukii assessed as mortality at 1.1 g/ha by direct application at 22 degC measured after 24 hr
|
Drosophila suzukii
|
100.0
%
|
|
Journal : Pest Manag Sci
Title : Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
Year : 2011
Volume : 67
Issue : 11
First Page : 1375
Last Page : 1385
Authors : Bruck DJ, Bolda M, Tanigoshi L, Klick J, Kleiber J, DeFrancesco J, Gerdeman B, Spitler H.
Abstract : BACKGROUND: The spotted wing Drosophila, Drosophila suzukii (Matsumura, 1931) (Diptera: Drosophilidae), is an invasive pest of small-fruit crops. Unlike most other Drosophila, this insect is able to oviposit into and damage ripe and ripening fruit, making it unmarketable. Because this is a new pest in the United States, it is necessary to identify registered insecticides to manage this insect effectively in conventional and organic production systems. RESULTS: The present laboratory bioassays and field trials identified a number of insecticides representing various modes of action that are effective in controlling D. suzukii. Products that performed well in the laboratory bioassay also performed well in the field, indicating that screening of new chemistries in the laboratory is a worthy exercise. Field application of pyrethoids, organophosphates or spinosyns provided 5-14 days of residual control of D. suzukii. The efficacy of the neonicotinoids as adulticides was not satisfactory compared with the other contact-mode-of-action chemistries. Based on the zero tolerance by the small-fruit industry and the individual effects mentioned above, neonicotinoids are not currently recommended for D. suzukii management. CONCLUSIONS: There are effective insecticides registered for controlling D. suzukii infestations in susceptible small-fruit crops.
