ENDOSULFAN

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Synonyms
Source Gaulton A, Kale N, van Westen GJ, Bellis LJ, Bento AP, Davies M, Hersey A, Papadatos G, Forster M, Wege P, Overington JP. A large-scale crop protection bioassay data set. Sci Data. 2015 Jul 7;2:150032. Read more ...

Structure

InChI Key RDYMFSUJUZBWLH-UHFFFAOYSA-N
Smiles ClC1=C(Cl)C2(Cl)C3COS(=O)OCC3C1(Cl)C2(Cl)Cl
InChI
InChI=1S/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H6Cl6O3S
Molecular Weight 406.93
AlogP 2.64
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 0.0
Polar Surface Area 54.74
Molecular species None
Aromatic Rings 0.0
Heavy Atoms 19.0
Assay Description Organism Bioactivity Reference
Effect on total amino acids level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 3.54 mg/g fresh wt) Oryza sativa 3.31 mg
Effect on total amino acids level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 3.91 mg/g fresh wt) Oryza sativa 3.38 mg
Effect on total protein level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 17.67 mg/g fresh wt) Oryza sativa 16.56 mg
Effect on total protein level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 21.67 mg/g fresh wt) Oryza sativa 18.33 mg
Effect on total phenols level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 17.08 mg/g dry wt) Oryza sativa 21.75 mg
Effect on total phenols level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 8.08 mg/g dry wt) Oryza sativa 10.0 mg
Effect on reducing sugar level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 8.37 mg/g dry wt) Oryza sativa 7.94 mg
Effect on reducing sugar level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 9.35 mg/g dry wt) Oryza sativa 8.26 mg
Effect on total sugar level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 34.05 mg/g dry wt) Oryza sativa 34.55 mg
Effect on total sugar level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf blade measured per gram of dry weight at 0.100% concentration (Rvb = 36.16 mg/g dry wt) Oryza sativa 34.02 mg
Effect on total amino acids level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 2.11 mg/g fresh wt) Oryza sativa 2.46 mg
Effect on total amino acids level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 2.58 mg/g fresh wt) Oryza sativa 2.4 mg
Effect on total protein level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 6.11 mg/g fresh wt) Oryza sativa 5.0 mg
Effect on total protein level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 7.06 mg/g fresh wt) Oryza sativa 7.78 mg
Insecticidal activity against L3 to L4 larvae of Diparopsis watersi assessed as mortality after 48 hr by leaf disc assay Diparopsis watersi 82.8 %
Insecticidal activity against Helicoverpa armigera assessed as time above which insecticide kills less than 50% of larvae by measuring index of persistence in presence of 24 mm of simulated rain applied at three days interval Helicoverpa armigera 5.2 day
Insecticidal activity against Helicoverpa armigera assessed as time above which insecticide kills less than 50% of larvae by measuring index of persistence under in absence of rain Helicoverpa armigera 8.7 day
Insecticidal activity against L5 larvae of Helicoverpa armigera assessed as mortality after 48 hr by leaf disk assay Helicoverpa armigera 92.5 %
Insecticidal activity against L4 larvae of Helicoverpa armigera assessed as mortality after 48 hr by leaf disk assay Helicoverpa armigera 89.5 %
Insecticidal activity against L3 larvae of Helicoverpa armigera assessed as mortality after 48 hr by leaf disk assay Helicoverpa armigera 94.1 %
Insecticidal activity against L2 larvae of Helicoverpa armigera assessed as mortality after 48 hr by leaf disk assay Helicoverpa armigera 91.5 %
Insecticidal activity against L1 larvae of Helicoverpa armigera assessed as mortality after 48 hr by leaf disk assay Helicoverpa armigera 93.3 %
Insecticidal activity against L3 to L4 larvae of Earias spp. assessed as mortality after 48 hr by leaf disk assay Earias 99.4 %
Insecticidal activity against Sogatella furcifera on insect-sensitive rice plant ARC6248 assessed as nymphal duration at 0.100% concentration (Rvb = 14.48 days) Sogatella furcifera 14.5 day
Insecticidal activity against Sogatella furcifera on insect-resistanct rice plant PR116 assessed as nymphal duration at 0.100% concentration (Rvb = 11.75 days) Sogatella furcifera 12.0 day
Insecticidal activity against Sogatella furcifera on insect-sensitive rice plant ARC6248 assessed as resurgence ratio at 0.100% concentration Sogatella furcifera 1.0
Insecticidal activity against Sogatella furcifera on insect-resistanct rice plant PR116 assessed as resurgence ratio at 0.100% concentration Sogatella furcifera 1.0
Insecticidal activity against Sogatella furcifera on insect-sensitive rice plant ARC6248 assessed as reproduction at 0.100% concentration Sogatella furcifera None
Insecticidal activity against Sogatella furcifera on insect-resistanct rice plant PR116 assessed as hopper population at 0.100% concentration Sogatella furcifera None
Effect on total phenols level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 12.75 mg/g dry wt) Oryza sativa 17.08 mg
Effect on total phenols level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 5.75 mg/g dry wt) Oryza sativa 7.83 mg
Effect on reducing sugar level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 6.41 mg/g dry wt) Oryza sativa 5.98 mg
Effect on reducing sugar level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 7.50 mg/g dry wt) Oryza sativa 7.17 mg
Effect on total sugar level in Sogatella furcifera-sensitive Oryza sativa (rice) plant ARC6248 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 25.98 mg/g dry wt) Oryza sativa 30.0 mg
Effect on total sugar level in Sogatella furcifera-resistanct Oryza sativa (rice) plant PR116 leaf sheath measured per gram of dry weight at 0.100% concentration (Rvb = 30.27 mg/g dry wt) Oryza sativa 28.12 mg
Insecticidal activity against Sogatella furcifera on insect-sensitive rice plant ARC6248 assessed as growth index at 0.100% concentration (Rvb = 2.38%) Sogatella furcifera 2.24 %
Insecticidal activity against Sogatella furcifera on insect-resistanct rice plant PR116 assessed as growth index at 0.100% concentration (Rvb = 6.02%) Sogatella furcifera 5.66 %
Insecticidal activity against Sogatella furcifera on insect-sensitive rice plant ARC6248 assessed as nymphal survival at 0.100% concentration (Rvb = 34.17%) Sogatella furcifera 32.22 %
Insecticidal activity against Sogatella furcifera on insect-resistanct rice plant PR116 assessed as nymphal survival at 0.100% concentration (Rvb = 70.28%) Sogatella furcifera 67.5 %
Resistance factor, ratio of LD50 for fourth-instar larval stage of Helicoverpa armigera field strain Gaschiga isolated from tomato plant to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-77 Helicoverpa armigera 0.7
Resistance factor, ratio of LD50 for fourth-instar larval stage of Helicoverpa armigera field strain Ngong to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-77 Helicoverpa armigera 0.1
Resistance factor, ratio of LD50 for fourth-instar larval stage of Helicoverpa armigera field strain Pitoa isolated from tomato plant to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-77 Helicoverpa armigera 1.0
Resistance factor, ratio of LD50 for fourth-instar larval stage of Helicoverpa armigera field strain Pitoa isolated from maize plant to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-77 Helicoverpa armigera 1.0
Resistance factor, ratio of LD50 for fourth-instar larval stage of pyrethroid-resistance Helicoverpa armigera laboratory strain GS-RR06 to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-77 Helicoverpa armigera 0.7
Insecticidal activity against fourth-instar larval stage of Helicoverpa armigera field strain Gaschiga isolated from tomato plant assessed as mortality applied topically onto thorax measured after 48 hr Helicoverpa armigera 25.9 microgAi/g
Insecticidal activity against fourth-instar larval stage of Helicoverpa armigera field strain Ngong isolated from cotton plant assessed as mortality applied topically onto thorax measured after 48 hr Helicoverpa armigera 34.0 microgAi/g
Insecticidal activity against fourth-instar larval stage of Helicoverpa armigera field strain Pitoa isolated from tomato plant assessed as mortality applied topically onto thorax measured after 48 hr Helicoverpa armigera 36.2 microgAi/g
Insecticidal activity against fourth-instar larval stage of Helicoverpa armigera field strain Pitoa isolated from maize plant assessed as mortality applied topically onto thorax measured after 48 hr Helicoverpa armigera 37.9 microgAi/g
Insecticidal activity against fourth-instar larval stage of pyrethroid-resistance Helicoverpa armigera laboratory strain GS-RR06 assessed as mortality applied topically onto thorax measured after 48 hr Helicoverpa armigera 27.5 microgAi/g
Insecticidal activity against fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-77 assessed as mortality applied topically onto thorax measured after 48 hr Helicoverpa armigera 37.6 microgAi/g
Insecticidal activity against Drosophila suzukii assessed as mortality at 1.1 g/ha by direct application at 22 degC measured after 24 hr Drosophila suzukii None

Cross References

Resources Reference
ChEMBL CHEMBL194399
PubChem 3224
SureChEMBL SCHEMBL21377
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