Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to genistein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.12
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to genistein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.07
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to genistein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.08
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to genistein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.05
umol
|
|
Drug metabolism in Silene noctiflora root assessed as transformation to genistein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.13
umol
|
|
Drug metabolism in Silene noctiflora root assessed as transformation to genistein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.08
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) shoot assessed as transformation to dihydrobiochanin A at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.27
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) shoot assessed as transformation to dihydrobiochanin A at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.0
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to dihydrobiochanin A at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.02
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to dihydrobiochanin A at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.01
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to dihydrobiochanin A at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.02
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to dihydrobiochanin A at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.0
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to dihydrobiochanin A at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.27
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to dihydrobiochanin A at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.05
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to dihydrobiochanin A at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.31
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to dihydrobiochanin A at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.38
umol
|
|
Drug metabolism in Silene noctiflora root assessed as transformation to dihydrobiochanin A at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.07
umol
|
|
Drug metabolism in Silene noctiflora root assessed as transformation to dihydrobiochanin A at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.01
umol
|
|
Drug uptake in Echinochloa crus-galli (barnyard grass) shoot at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.67
umol
|
|
Drug uptake in Echinochloa crus-galli (barnyard grass) shoot at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.05
umol
|
|
Drug uptake in Geranium molle shoot at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
1.13
umol
|
|
Drug uptake in Silene noctiflora shoot at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
1.11
umol
|
|
Drug uptake in Geranium molle shoot at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
1.0
umol
|
|
Drug uptake in Silene noctiflora shoot at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.76
umol
|
|
Drug uptake in Echinochloa crus-galli (barnyard grass) root at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
2.13
umol
|
|
Drug uptake in Echinochloa crus-galli (barnyard grass) root at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
1.75
umol
|
|
Drug uptake in Geranium molle root at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
11.46
umol
|
|
Drug uptake in Geranium molle root at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
9.93
umol
|
|
Drug uptake in Silene noctiflora root at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
4.54
umol
|
|
Drug recovery in leaf of Lolium perenne (perennial ryegrass) at 50 ng/g by LC-MS analysis
|
Lolium perenne
|
93.0
%
|
|
Drug uptake in Silene noctiflora root at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
4.65
umol
|
|
Drug recovery in leaf of Lolium perenne (perennial ryegrass) at 5 ng/g by LC-MS analysis
|
Lolium perenne
|
93.0
%
|
|
Phytotoxicity against Amaranthus caudatus assessed as root growth inhibition at 100 to 400 uM after 2 weeks by agar medium bioassay
|
Amaranthus caudatus
|
None
|
|
Phytotoxicity against Lolium perenne (perennial ryegrass) assessed as root growth inhibition at 100 to 400 uM after 2 weeks by agar medium bioassay
|
Lolium perenne
|
None
|
|
Phytotoxicity against Echinochloa crus-galli (barnyard grass) assessed as root growth inhibition at 100 to 400 uM after 2 weeks by agar medium bioassay
|
Echinochloa crus-galli
|
None
|
|
Phytotoxicity against Geranium molle assessed as root growth inhibition after 2 weeks by agar medium bioassay
|
Geranium molle
|
400000.0
nM
|
|
Phytotoxicity against Geranium molle assessed as root growth inhibition after 2 weeks by agar medium bioassay
|
Geranium molle
|
400.0
uM
|
|
Phytotoxicity against Silene noctiflora assessed as root growth inhibition after 2 weeks by agar medium bioassay
|
Silene noctiflora
|
35800.0
nM
|
|
Phytotoxicity against Silene noctiflora assessed as root growth inhibition after 2 weeks by agar medium bioassay
|
Silene noctiflora
|
5.2
uM
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) shoot assessed as transformation to sissotrin at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.0
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) shoot assessed as transformation to sissotrin at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.0
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to sissotrin at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
2.41
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to sissotrin at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
1.5
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to sissotrin at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
4.34
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to sissotrin at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
2.36
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to sissotrin at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
1.0
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to sissotrin at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.48
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to sissotrin at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
123.61
umol
|
|
Drug metabolism in Silene noctiflora root assessed as transformation to sissotrin at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
2.99
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to sissotrin at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
36.06
umol
|
|
Drug metabolism in Silene noctiflora root assessed as transformation to sissotrin at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
1.72
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to p-coumaric acid at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.03
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to p-coumaric acid at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.01
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to p-coumaric acid at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.11
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to p-coumaric acid at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.15
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to p-coumaric acid at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.05
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to p-coumaric acid at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.06
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) shoot assessed as transformation to pratensein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.24
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) shoot assessed as transformation to pratensein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.47
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to pratensein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.05
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to pratensein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.02
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to pratensein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.06
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to pratensein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.1
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to pratensein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.35
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) root assessed as transformation to pratensein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.38
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to pratensein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.32
umol
|
|
Drug metabolism in Geranium molle root assessed as transformation to pratensein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.66
umol
|
|
Drug metabolism in Silene noctiflora root assessed as transformation to pratensein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.11
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) shoot assessed as transformation to genistein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.2
umol
|
|
Drug metabolism in Echinochloa crus-galli (barnyard grass) shoot assessed as transformation to genistein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Echinochloa crus-galli
|
0.28
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to genistein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.12
umol
|
|
Drug metabolism in Geranium molle shoot assessed as transformation to genistein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Geranium molle
|
0.09
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to genistein at 400 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.15
umol
|
|
Drug metabolism in Silene noctiflora shoot assessed as transformation to genistein at 20 uM after 14 days measured per gm of dry weight by LC-MS analysis
|
Silene noctiflora
|
0.24
umol
|
|
Apparent volume of distribution in Rattus norvegicus Sprague-Dawley (rat) at 5 mg/kg, iv
|
Rattus norvegicus
|
10.56
L/Kg
|
|
Total clearance in Rattus norvegicus Sprague-Dawley (rat) at 5 mg/kg, iv
|
Rattus norvegicus
|
261.67
mL.min-1.kg-1
|
|
Apparent elimination half life in Rattus norvegicus Sprague-Dawley (rat) at 50 mg/kg, po
|
Rattus norvegicus
|
13.73
hr
|
|
Apparent elimination half life in Rattus norvegicus Sprague-Dawley (rat) at 5 mg/kg, iv
|
Rattus norvegicus
|
1.0
hr
|
|
Tmax in Rattus norvegicus Sprague-Dawley (rat) at 50 mg/kg, po
|
Rattus norvegicus
|
0.42
hr
|
|
Cmax in Rattus norvegicus Sprague-Dawley (rat) at 5 mg/kg, iv
|
Rattus norvegicus
|
1.11
ug.mL-1
|
|
AUC (0 to t) in Rattus norvegicus Sprague-Dawley (rat) at 5 mg/kg, iv
|
Rattus norvegicus
|
480.8
hr.ng/ml
|
|
Cmax in Rattus norvegicus Sprague-Dawley (rat) at 50 mg/kg, po
|
Rattus norvegicus
|
0.0335
ug.mL-1
|
|
AUC (0 to t) in Rattus norvegicus Sprague-Dawley (rat) at 50 mg/kg, po
|
Rattus norvegicus
|
220.29
hr.ng/ml
|
|