|
Cytotoxicity against Homo sapiens (human) SW480 cell by MTT assay
|
Homo sapiens
|
18130.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents
Year : 2011
Volume : 20
Issue : 5
First Page : 576
Last Page : 586
Authors : Murty MSR, Ram KR, Rao RV, Yadav JS, Rao JV, Cheriyan VT, Anto RJ
|
Cytotoxicity against Homo sapiens (human) A549 cell by MTT assay
|
Homo sapiens
|
24590.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents
Year : 2011
Volume : 20
Issue : 5
First Page : 576
Last Page : 586
Authors : Murty MSR, Ram KR, Rao RV, Yadav JS, Rao JV, Cheriyan VT, Anto RJ
|
Cytotoxicity against Homo sapiens (human) MCF7 cell by MTT assay
|
Homo sapiens
|
21390.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents
Year : 2011
Volume : 20
Issue : 5
First Page : 576
Last Page : 586
Authors : Murty MSR, Ram KR, Rao RV, Yadav JS, Rao JV, Cheriyan VT, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HeLa cell by MTT assay
|
Homo sapiens
|
17310.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents
Year : 2011
Volume : 20
Issue : 5
First Page : 576
Last Page : 586
Authors : Murty MSR, Ram KR, Rao RV, Yadav JS, Rao JV, Cheriyan VT, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HCT116 cells by MTT assay
|
Homo sapiens
|
10000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) SKBR3 cells by MTT assay
|
Homo sapiens
|
27000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HeLa cells by MTT assay
|
Homo sapiens
|
17000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) H1299 cells assessed as cell viability at 25 uM by MTT assay
|
Homo sapiens
|
44.7
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) H1299 cells assessed as cell viability at 10 uM by MTT assay
|
Homo sapiens
|
62.4
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) H1299 cells assessed as cell viability at 5 uM by MTT assay
|
Homo sapiens
|
86.1
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) A375 cells assessed as cell viability at 25 uM by MTT assay
|
Homo sapiens
|
50.2
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) A375 cells assessed as cell viability at 10 uM by MTT assay
|
Homo sapiens
|
72.3
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) A375 cells assessed as cell viability at 5 uM by MTT assay
|
Homo sapiens
|
92.0
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HCT116 cells assessed as cell viability at 25 uM by MTT assay
|
Homo sapiens
|
22.4
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HCT116 cells assessed as cell viability at 10 uM by MTT assay
|
Homo sapiens
|
49.6
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HCT116 cells assessed as cell viability at 5 uM by MTT assay
|
Homo sapiens
|
61.6
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) SKBR3 cells assessed as cell viability at 25 uM by MTT assay
|
Homo sapiens
|
56.5
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) SKBR3 cells assessed as cell viability at 10 uM by MTT assay
|
Homo sapiens
|
74.0
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) SKBR3 cells assessed as cell viability at 5 uM by MTT assay
|
Homo sapiens
|
53.7
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HeLa cells assessed as cell viability at 5 uM by MTT assay
|
Homo sapiens
|
78.3
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HeLa cells assessed as cell viability at 10 uM by MTT assay
|
Homo sapiens
|
53.7
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Cytotoxicity against Homo sapiens (human) HeLa cells assessed as cell viability at 25 uM by MTT assay
|
Homo sapiens
|
28.0
%
|
|
Journal : Med Chem Res
Title : Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents
Year : 2012
Volume : 21
Issue : 10
First Page : 3161
Last Page : 3169
Authors : Murty MSR, Rao BR, Ram KR, Yadav JS, Antony J, Anto RJ
|
Antioxidant activity assessed as DPPH scavenging activity after 30 min by spectrophotometry
|
None
|
None
|
|
Journal : Med Chem Res
Title : Synthesis and evaluation of DPPH and anti-inflammatory activities of 2,6-bisbenzylidenecyclohexanone and pyrazoline derivatives
Year : 2012
Volume : 21
Issue : 3
First Page : 333
Last Page : 344
Authors : Lam KW, Tham CL, Liew CY, Syahida A, Abdul Rahman MB, Israf DA, Lajis NH
|
Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced nitric oxide production after 17 to 20 hr by Griess assay
|
Mus musculus
|
21580.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis and evaluation of DPPH and anti-inflammatory activities of 2,6-bisbenzylidenecyclohexanone and pyrazoline derivatives
Year : 2012
Volume : 21
Issue : 3
First Page : 333
Last Page : 344
Authors : Lam KW, Tham CL, Liew CY, Syahida A, Abdul Rahman MB, Israf DA, Lajis NH
|
Down regulation of rhlA expression in Pseudomonas aeruginosa PAO1 at 3 ug/mL by microarray gene expression analysis
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Down regulation of lasI expression in Pseudomonas aeruginosa PAO1 at 3 ug/mL by microarray gene expression analysis
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Down regulation of phzD expression in Pseudomonas aeruginosa PAO1 at 3 ug/mL by microarray gene expression analysis
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Effect on QS system related genes in Pseudomonas aeruginosa PAO1 at 3 ug/mL by microarray gene expression analysis
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Antimicrobial activity against Pseudomonas aeruginosa PAO1 infected in Arabidopsis thaliana Col-0 assessed as change in bacterial count in presence of AHL/3-oxo-HSL
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Antimicrobial activity against Pseudomonas aeruginosa PAO1 infected in Arabidopsis thaliana Col-0 assessed as inhibition of biofilm formation in roots at 3 ug/mL measured 7 days post dose
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Antimicrobial activity against Pseudomonas aeruginosa PAO1 infected in Arabidopsis thaliana Col-0 assessed as protection against infection of roots at 3 ug/mL measured 7 days post dose
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Down regulation of QS system in Pseudomonas aeruginosa PAO1 assessed as reduction in total homoserine lactone production at 5 ug/mL by HPLC relative to untreated control
|
Pseudomonas aeruginosa PAO1
|
3.0
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Down regulation of QS system in Pseudomonas aeruginosa PAO1 assessed as reduction in C4-HSL production at 1 ug/mL by HPLC
|
Pseudomonas aeruginosa PAO1
|
2.0
%
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Down regulation of QS system in Pseudomonas aeruginosa PAO1 assessed as reduction in 3-oxo-C12-HSL production at 1 ug/mL by HPLC
|
Pseudomonas aeruginosa PAO1
|
25.0
%
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Down regulation of virulence factor production in Pseudomonas aeruginosa PAO1 assessed as reduction in elastase production at 1 to 5 ug/mL relative to untreated control
|
Pseudomonas aeruginosa PAO1
|
2.0
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Down regulation of virulence factor production in Pseudomonas aeruginosa PAO1 assessed as reduction in protease production at 1 to 5 ug/mL relative to untreated control
|
Pseudomonas aeruginosa PAO1
|
2.0
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Down regulation of virulence factor production in Pseudomonas aeruginosa PAO1 assessed as reduction in pyocyanin production at 1.5 to 3 ug/mL
|
Pseudomonas aeruginosa PAO1
|
60.0
%
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Inhibition of biofilm formation of Pseudomonas aeruginosa PAO1 at 2 to 3 ug/mL by confocal scanning laser microscopy
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Inhibition of biofilm formation of Pseudomonas aeruginosa PAO1 at 1.5 to 3 ug/mL by crystal violet staining method
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Growth inhibition of Pseudomonas aeruginosa PAO1 planktonic forms
|
Pseudomonas aeruginosa PAO1
|
30.0
ug.mL-1
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Growth inhibition of Pseudomonas aeruginosa PAO1 planktonic forms at >5 ug/mL
|
Pseudomonas aeruginosa PAO1
|
None
|
|
Journal : J Agric Food Chem
Title : Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models.
Year : 2008
Volume : 56
Issue : 6
First Page : 1955
Last Page : 1962
Authors : Rudrappa T, Bais HP.
Abstract : The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated. The effect of curcumin on PAO1 virulence was studied by employing in vitro assays for virulence factor production, Arabidopsis thaliana/Caenorhabditis elegans pathogenicity models, and whole genome microarray analysis. It is shown that the curcumin inhibits PAO1 virulence factors such as biofilm formation, pyocyanin biosynthesis, elastase/protease activity, and acyl homoserine lactone (HSL) production. As a consequence of this, curcumin treatment resulted in the reduced pathogenicity of P. aeruginosa-C. elegans and P. aeruginosa-A. thaliana infection models. In addition, transcriptome analysis of curcumin-treated PAO1 revealed down-regulation of 31 quorum sensing (QS) genes, of which many have already been reported for virulence. The supplementation of HSLs along with the curcumin treatment resulted in increased pathogencity and recovery of higher bacterial titers in a plant pathogenecity model. These data reveal the involvement of curcumin in QS interruption to reduce pathogenicity. Curcumin attenuates PAO1 virulence by down-regulation of virulence factors, QS, and biofilm initiation genes. The effect of curcumin on multiple targets such as virulence, QS, and biofilm initiation makes curcumin a potential supplemental molecule for the treatment of P. aeruginosa infections.
|
Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay
|
Mus musculus
|
3.4
mM
|
|
Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay
|
Mus musculus
|
4.8
mM
|
|
Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay
|
Mus musculus
|
100.0
mM
|
|
Journal : Med Chem Res
Title : Synthesis and evaluation of curcumin analogues as cytotoxic agents
Year : 2010
Volume : 19
Issue : 5
First Page : 413
Last Page : 430
Authors : Fadda AA, Badria FA, El-Attar KM
|
Cytotoxicity against Homo sapiens (human) K562 cells
|
Homo sapiens
|
54300.0
nM
|
|
Journal : Med Chem Res
Title : Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation
Year : 2011
Volume : 20
Issue : 4
First Page : 503
Last Page : 510
Authors : Aryapour H, Riazi GH, Foroumadi A, Ahmadian S, Shafiee A, Karima O, Mahdavi M, Emami S, Sorkhi M, Khodadady S
|
Cytotoxicity against Homo sapiens (human) SK-N-MC cells after 72 hr by MTT assay
|
Homo sapiens
|
57400.0
nM
|
|
Journal : Med Chem Res
Title : Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation
Year : 2011
Volume : 20
Issue : 4
First Page : 503
Last Page : 510
Authors : Aryapour H, Riazi GH, Foroumadi A, Ahmadian S, Shafiee A, Karima O, Mahdavi M, Emami S, Sorkhi M, Khodadady S
|
Cytotoxicity against Homo sapiens (human) K562 cells after 72 hr by MTT assay
|
Homo sapiens
|
49200.0
nM
|
|
Journal : Med Chem Res
Title : Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation
Year : 2011
Volume : 20
Issue : 4
First Page : 503
Last Page : 510
Authors : Aryapour H, Riazi GH, Foroumadi A, Ahmadian S, Shafiee A, Karima O, Mahdavi M, Emami S, Sorkhi M, Khodadady S
|
Inhibition of Ovis aries (sheep) brain tubulin polymerization assessed as microtubule assembly after 15 min by measuring turbidity based spectroscopic analysis
|
Ovis aries
|
26600.0
nM
|
|
Journal : Med Chem Res
Title : Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation
Year : 2011
Volume : 20
Issue : 4
First Page : 503
Last Page : 510
Authors : Aryapour H, Riazi GH, Foroumadi A, Ahmadian S, Shafiee A, Karima O, Mahdavi M, Emami S, Sorkhi M, Khodadady S
|
Antiproliferative activity against Homo sapiens (human) MCF7 cells
|
Homo sapiens
|
12000.0
nM
|
|
Journal : Med Chem Res
Title : Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation
Year : 2011
Volume : 20
Issue : 4
First Page : 503
Last Page : 510
Authors : Aryapour H, Riazi GH, Foroumadi A, Ahmadian S, Shafiee A, Karima O, Mahdavi M, Emami S, Sorkhi M, Khodadady S
|
Antiproliferative activity against Homo sapiens (human) HeLa cells
|
Homo sapiens
|
13800.0
nM
|
|
Journal : Med Chem Res
Title : Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation
Year : 2011
Volume : 20
Issue : 4
First Page : 503
Last Page : 510
Authors : Aryapour H, Riazi GH, Foroumadi A, Ahmadian S, Shafiee A, Karima O, Mahdavi M, Emami S, Sorkhi M, Khodadady S
|
Inhibition of Homo sapiens (human) topoisomerase 1 assessed as relaxation of supercoiled DNA up to 25 uM by agarose gel electrophoresis
|
Homo sapiens
|
None
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Inhibition of Homo sapiens (human) topoisomerase 2 assessed as decatenation of KDNA by agarose gel electrophoresis
|
Homo sapiens
|
15000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Inhibition of Homo sapiens (human) topoisomerase 1 assessed as production of nicked DNA up to 25 uM by agarose gel electrophoresis
|
Homo sapiens
|
None
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Cytotoxicity against Sus scrofa (pig) LLC-PK1 cells up to 25 uM by neutral red staining
|
Sus scrofa
|
None
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells up to 25 uM by neutral red staining
|
Chlorocebus aethiops
|
None
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Cytotoxicity against Homo sapiens (human) SKOV3 cells up to 25 uM by neutral red staining
|
Homo sapiens
|
None
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Cytotoxicity against Homo sapiens (human) SK-MEL cells by neutral red staining
|
Homo sapiens
|
13750.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Cytotoxicity against Homo sapiens (human) KB cells by neutral red staining
|
Homo sapiens
|
25000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Cytotoxicity against Homo sapiens (human) BT549 cells by neutral red staining
|
Homo sapiens
|
10500.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents
Year : 2012
Volume : 21
Issue : 6
First Page : 874
Last Page : 890
Authors : Al-Wabli RI, AboulWafa OM, Youssef KM
|
Fungicidal activity against Blumeria graminis infected first-leaf stage of barley plant at 125 mg/l applied as spray under green house conditions relative to control
|
Blumeria graminis
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Blumeria graminis infected first-leaf stage of barley plant at 250 mg/l applied as spray under green house conditions relative to control
|
Blumeria graminis
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Blumeria graminis infected first-leaf stage of barley plant at 500 mg/l applied as spray under green house conditions relative to control
|
Blumeria graminis
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Blumeria graminis infected first-leaf stage of barley plant at 1000 mg/l applied as spray under green house conditions relative to control
|
Blumeria graminis
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Puccinia recondita infected first leaf stage of wheat plant at 125 mg/l applied as spray after 10 days under green house conditions relative to control
|
Puccinia recondita
|
63.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Puccinia recondita infected first leaf stage of wheat plant at 250 mg/l applied as spray after 10 days under green house conditions relative to control
|
Puccinia recondita
|
76.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Puccinia recondita infected first leaf stage of wheat plant at 500 mg/l applied as spray after 10 days under green house conditions relative to control
|
Puccinia recondita
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Puccinia recondita infected first leaf stage of wheat plant at 1000 mg/l applied as spray after 10 days under green house conditions relative to control
|
Puccinia recondita
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Phytophthora infestans infected second leaf-stage of tomato plant at 125 mg/l applied as spray after 4 days under green house conditions relative to control
|
Phytophthora infestans
|
57.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Phytophthora infestans infected second leaf-stage of tomato plant at 250 mg/l applied as spray after 4 days under green house conditions relative to control
|
Phytophthora infestans
|
85.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Phytophthora infestans infected second leaf-stage of tomato plant at 500 mg/l applied as spray after 4 days under green house conditions relative to control
|
Phytophthora infestans
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Phytophthora infestans infected second leaf-stage of tomato plant at 1000 mg/l applied as spray after 4 days under green house conditions relative to control
|
Phytophthora infestans
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Botryotinia fuckeliana infected first-leaf stage of cucumber plant at 125 mg/l applied as spray after 4 to 5 days under green house conditions relative to control
|
Botryotinia fuckeliana
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Botryotinia fuckeliana infected first-leaf stage of cucumber plant at 250 mg/l applied as spray after 4 to 5 days under green house conditions relative to control
|
Botryotinia fuckeliana
|
15.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Botryotinia fuckeliana infected first-leaf stage of cucumber plant at 500 mg/l applied as spray after 4 to 5 days under green house conditions relative to control
|
Botryotinia fuckeliana
|
40.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Botryotinia fuckeliana infected first-leaf stage of cucumber plant at 1000 mg/l applied as spray after 4 to 5 days under green house conditions relative to control
|
Botryotinia fuckeliana
|
70.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Rhizoctonia solani infected in third leaf stage of rice plant at 125 mg/l applied as spray after 5 days under green house conditions relative to control
|
Rhizoctonia solani
|
26.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Rhizoctonia solani infected in third leaf stage of rice plant at 250 mg/l applied as spray after 5 days under green house conditions relative to control
|
Rhizoctonia solani
|
45.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Rhizoctonia solani infected in third leaf stage of rice plant at 1000 mg/l applied as spray after 5 days under green house conditions relative to control
|
Rhizoctonia solani
|
85.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Rhizoctonia solani infected in third leaf stage of rice plant at 500 mg/l applied as spray after 5 days under green house conditions relative to control
|
Rhizoctonia solani
|
63.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Magnaporthe grisea infected second leaf stage of rice plant at 125 mg/l applied as spray after 5 days under green house conditions relative to control
|
Magnaporthe grisea
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Magnaporthe grisea infected second leaf stage of rice plant at 250 mg/l applied as spray after 5 days under green house conditions relative to control
|
Magnaporthe grisea
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Magnaporthe grisea infected second leaf stage of rice plant at 500 mg/l applied as spray after 5 days under green house conditions relative to control
|
Magnaporthe grisea
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Fungicidal activity against Magnaporthe grisea infected second leaf stage of rice plant at 1000 mg/l applied as spray after 5 days under green house conditions relative to control
|
Magnaporthe grisea
|
0.0
%
|
|
Journal : J Agric Food Chem
Title : Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse.
Year : 2003
Volume : 51
Issue : 6
First Page : 1578
Last Page : 1581
Authors : Kim MK, Choi GJ, Lee HS.
Abstract : Fungicidal activity of Curcuma longa rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia oryzae, and Rhizoctonia solani was tested using a whole plant method in vivo. It was compared with synthetic fungicides and four commercially available compounds derived from C. longa. The response varied with the tested plant pathogen. At 1000 mg/L, the hexane extract of C. longa showed fungicidal activities against E.graminis, P. infestans, and R. solani, and the ethyl acetate extract of C. longa showed fungicidal activities against B. cineria, P. infestans, Pu. recondita, and R. solani. Curcumin was isolated from the ethyl acetate fraction using chromatographic techniques and showed fungicidal activities against P. infestans, Pu. recondita, and R. solani with 100, 100, and 63% control values at 500 mg/L and 85, 76, and 45% control values at 250 mg/L, respectively. In the test with components derived from C. longa, turmerone exhibited weak activity against E. graminis, but no activity was observed from treatments with borneol, 1,8-cineole, sabinene, and turmerone. In comparison, potent fungicidal activity with chlorothalonil against P. infestans at 50 mg/L and dichlofluanid against B. cinerea at 50 mg/L was exhibited. These results may be an indication of at least one of the fungicidal actions of curcumin derived from C. longa.
|
Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as cell viability at 20 ug/ml by trypan blue assay
|
Homo sapiens
|
19.0
%
|
|
Journal : Med Chem Res
Title : Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents
Year : 2013
Volume : 22
Issue : 3
First Page : 1147
Last Page : 1162
Authors : Bayomi SM, El-Kashef HA, El-Ashmawy MB, Nasr MNA, El-Sherbeny MA, Badria FA, Abou-zeid LA, Ghaly MA, Abdel-Aziz NI
|
Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability at 20 ug/ml by trypan blue assay
|
Chlorocebus aethiops
|
24.0
%
|
|
Journal : Med Chem Res
Title : Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents
Year : 2013
Volume : 22
Issue : 3
First Page : 1147
Last Page : 1162
Authors : Bayomi SM, El-Kashef HA, El-Ashmawy MB, Nasr MNA, El-Sherbeny MA, Badria FA, Abou-zeid LA, Ghaly MA, Abdel-Aziz NI
|
Cytotoxicity against Homo sapiens (human) WI38 cells assessed as cell viability at 20 ug/ml by trypan blue assay
|
Homo sapiens
|
51.0
%
|
|
Journal : Med Chem Res
Title : Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents
Year : 2013
Volume : 22
Issue : 3
First Page : 1147
Last Page : 1162
Authors : Bayomi SM, El-Kashef HA, El-Ashmawy MB, Nasr MNA, El-Sherbeny MA, Badria FA, Abou-zeid LA, Ghaly MA, Abdel-Aziz NI
|
Cytotoxicity against Homo sapiens (human) HepG2 cells assessed as cell viability at 20 ug/ml by trypan blue assay
|
Homo sapiens
|
18.0
%
|
|
Journal : Med Chem Res
Title : Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents
Year : 2013
Volume : 22
Issue : 3
First Page : 1147
Last Page : 1162
Authors : Bayomi SM, El-Kashef HA, El-Ashmawy MB, Nasr MNA, El-Sherbeny MA, Badria FA, Abou-zeid LA, Ghaly MA, Abdel-Aziz NI
|
Anticancer activity against Homo sapiens (human) A549 cells assessed as inhibition of cell viability after 72 hr by MTT assay
|
Homo sapiens
|
22000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: novel hybrid heterocycles as anticancer agents
Year : 2013
Volume : 22
Issue : 10
First Page : 4980
Last Page : 4991
Authors : Murty MSR, Ramalingeswara Rao B, Katiki MR, Nath LR, Anto RJ
|
Anticancer activity against Homo sapiens (human) HepG2 cells assessed as inhibition of cell viability after 72 hr by MTT assay
|
Homo sapiens
|
16000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: novel hybrid heterocycles as anticancer agents
Year : 2013
Volume : 22
Issue : 10
First Page : 4980
Last Page : 4991
Authors : Murty MSR, Ramalingeswara Rao B, Katiki MR, Nath LR, Anto RJ
|
Anticancer activity against Homo sapiens (human) HeLa cells assessed as inhibition of cell viability after 72 hr by MTT assay
|
Homo sapiens
|
17000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: novel hybrid heterocycles as anticancer agents
Year : 2013
Volume : 22
Issue : 10
First Page : 4980
Last Page : 4991
Authors : Murty MSR, Ramalingeswara Rao B, Katiki MR, Nath LR, Anto RJ
|
Anticancer activity against Homo sapiens (human) A431 cells assessed as inhibition of cell viability after 72 hr by MTT assay
|
Homo sapiens
|
22000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: novel hybrid heterocycles as anticancer agents
Year : 2013
Volume : 22
Issue : 10
First Page : 4980
Last Page : 4991
Authors : Murty MSR, Ramalingeswara Rao B, Katiki MR, Nath LR, Anto RJ
|
Anticancer activity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell viability after 72 hr by MTT assay
|
Homo sapiens
|
26000.0
nM
|
|
Journal : Med Chem Res
Title : Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1,3,4-oxadiazole-2-thiol: novel hybrid heterocycles as anticancer agents
Year : 2013
Volume : 22
Issue : 10
First Page : 4980
Last Page : 4991
Authors : Murty MSR, Ramalingeswara Rao B, Katiki MR, Nath LR, Anto RJ
