|
Drug recovery in leaf of Lolium perenne (perennial ryegrass) at 50 ng/g by LC-MS analysis
|
Lolium perenne
|
65.0
%
|
|
Journal : J Agric Food Chem
Title : Phytotoxic effect, uptake, and transformation of biochanin A in selected weed species.
Year : 2012
Volume : 60
Issue : 43
First Page : 10715
Last Page : 10722
Authors : Shajib MT, Pedersen HA, Mortensen AG, Kudsk P, Fomsgaard IS.
Abstract : Certain isoflavones are plant growth inhibitors, and biochanin A is a major isoflavone in clover species used for weed management. The effect of biochanin A on the monocot weed species Echinochloa crus-galli L. and Lolium perenne L. and dicot species Silene noctiflora L., Geranium molle L., and Amaranthus caudatus L. was evaluated in agar medium bioassays. S. noctiflora and G. molle root growth was progressively inhibited with increasing concentrations of biochanin A, whereas the monocot species were unaffected. With regard to the dicot species, S. noctiflora (EC(50) = 35.80 μM and EC(25) = 5.20 μM) was more susceptible than G. molle (EC(50), EC(25) > 400 μM). S. noctiflora, G. molle, and E. crus-galli root and shoot samples, representing a susceptible, a less susceptible, and a nonsusceptible species, respectively, were analyzed by LC-MS to quantify biochanin A and its transformation products. Biochanin A and its known transformation products genistein, dihydrobiochanin A, pratensein, and p-coumaric acid were quantified. Sissotrin was identified and quantified while assigning unknown peaks. The treated root samples contained more biochanin A, genistein, pratensein, and dihydrobiochanin A than shoot samples.
|
Drug recovery in leaf of Lolium perenne (perennial ryegrass) at 5 ng/g by LC-MS analysis
|
Lolium perenne
|
81.0
%
|
|
Journal : J Agric Food Chem
Title : Phytotoxic effect, uptake, and transformation of biochanin A in selected weed species.
Year : 2012
Volume : 60
Issue : 43
First Page : 10715
Last Page : 10722
Authors : Shajib MT, Pedersen HA, Mortensen AG, Kudsk P, Fomsgaard IS.
Abstract : Certain isoflavones are plant growth inhibitors, and biochanin A is a major isoflavone in clover species used for weed management. The effect of biochanin A on the monocot weed species Echinochloa crus-galli L. and Lolium perenne L. and dicot species Silene noctiflora L., Geranium molle L., and Amaranthus caudatus L. was evaluated in agar medium bioassays. S. noctiflora and G. molle root growth was progressively inhibited with increasing concentrations of biochanin A, whereas the monocot species were unaffected. With regard to the dicot species, S. noctiflora (EC(50) = 35.80 μM and EC(25) = 5.20 μM) was more susceptible than G. molle (EC(50), EC(25) > 400 μM). S. noctiflora, G. molle, and E. crus-galli root and shoot samples, representing a susceptible, a less susceptible, and a nonsusceptible species, respectively, were analyzed by LC-MS to quantify biochanin A and its transformation products. Biochanin A and its known transformation products genistein, dihydrobiochanin A, pratensein, and p-coumaric acid were quantified. Sissotrin was identified and quantified while assigning unknown peaks. The treated root samples contained more biochanin A, genistein, pratensein, and dihydrobiochanin A than shoot samples.
|
Drug metabolism in fourth instar larval stage of Spodoptera litura assessed in excrements after feeding diet containing compound by HPLC analysis
|
Spodoptera litura
|
None
|
|
Journal : J Agric Food Chem
Title : Secondary metabolites from Glycine soja and their growth inhibitory effect against Spodoptera litura.
Year : 2011
Volume : 59
Issue : 11
First Page : 6004
Last Page : 6010
Authors : Zhou YY, Luo SH, Yi TS, Li CH, Luo Q, Hua J, Liu Y, Li SH.
Abstract : The wild soybean (Glycine soja Sieb. et Zucc) has been reported to be relatively resistant to insect and pathogenic pests. However, the responsible secondary metabolites in the aerial part of this important plant are largely unknown. From the aerial part of G. soja, 13 compounds were isolated and identified, including seven isoflavonoids (1-7), a cyclitol (8), two sterol derivatives (9 and 10), and three triterpenoids (11-13). Compound 7 is a new isoflavonoid, and compounds 9 and 10 are reported as natural products for the first time. The growth inhibitory activity of 1, 3, 4, and 8 against the larvae of Spodoptera litura was investigated. The most abundant isoflavonoid in the aerial part of G. soja, daidzein (1), which could not be metabolized by S. litura, was found to inhibit the insect larvae growth significantly in 3 days after feeding diets containing the compound. Compounds 3, 4, and 8, which could be partially or completely metabolized, were inactive. Our results suggested that the isoflavonoid daidzein (1) might function as a constitutive defense component in G. soja against insect pests.
|
Insecticidal activity against fourth instar larval stage of Spodoptera litura in glandless fresh cabbage leaves assessed as growth inhibition measured 3 days after feeding diet containing compound
|
Spodoptera litura
|
None
|
|
Journal : J Agric Food Chem
Title : Secondary metabolites from Glycine soja and their growth inhibitory effect against Spodoptera litura.
Year : 2011
Volume : 59
Issue : 11
First Page : 6004
Last Page : 6010
Authors : Zhou YY, Luo SH, Yi TS, Li CH, Luo Q, Hua J, Liu Y, Li SH.
Abstract : The wild soybean (Glycine soja Sieb. et Zucc) has been reported to be relatively resistant to insect and pathogenic pests. However, the responsible secondary metabolites in the aerial part of this important plant are largely unknown. From the aerial part of G. soja, 13 compounds were isolated and identified, including seven isoflavonoids (1-7), a cyclitol (8), two sterol derivatives (9 and 10), and three triterpenoids (11-13). Compound 7 is a new isoflavonoid, and compounds 9 and 10 are reported as natural products for the first time. The growth inhibitory activity of 1, 3, 4, and 8 against the larvae of Spodoptera litura was investigated. The most abundant isoflavonoid in the aerial part of G. soja, daidzein (1), which could not be metabolized by S. litura, was found to inhibit the insect larvae growth significantly in 3 days after feeding diets containing the compound. Compounds 3, 4, and 8, which could be partially or completely metabolized, were inactive. Our results suggested that the isoflavonoid daidzein (1) might function as a constitutive defense component in G. soja against insect pests.
|
Antifeedant activity against fourth instar larval stage of Spodoptera litura on fresh cabbage leaves
|
Spodoptera litura
|
None
|
|
Journal : J Agric Food Chem
Title : Secondary metabolites from Glycine soja and their growth inhibitory effect against Spodoptera litura.
Year : 2011
Volume : 59
Issue : 11
First Page : 6004
Last Page : 6010
Authors : Zhou YY, Luo SH, Yi TS, Li CH, Luo Q, Hua J, Liu Y, Li SH.
Abstract : The wild soybean (Glycine soja Sieb. et Zucc) has been reported to be relatively resistant to insect and pathogenic pests. However, the responsible secondary metabolites in the aerial part of this important plant are largely unknown. From the aerial part of G. soja, 13 compounds were isolated and identified, including seven isoflavonoids (1-7), a cyclitol (8), two sterol derivatives (9 and 10), and three triterpenoids (11-13). Compound 7 is a new isoflavonoid, and compounds 9 and 10 are reported as natural products for the first time. The growth inhibitory activity of 1, 3, 4, and 8 against the larvae of Spodoptera litura was investigated. The most abundant isoflavonoid in the aerial part of G. soja, daidzein (1), which could not be metabolized by S. litura, was found to inhibit the insect larvae growth significantly in 3 days after feeding diets containing the compound. Compounds 3, 4, and 8, which could be partially or completely metabolized, were inactive. Our results suggested that the isoflavonoid daidzein (1) might function as a constitutive defense component in G. soja against insect pests.
|
Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 0.2 ug/mL measured within 24 hr by fumigation assay
|
Tribolium castaneum
|
None
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality measured after 24 hr by fumigation assay
|
Tribolium castaneum
|
0.18
ug.mL-1
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay
|
Tribolium castaneum
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Tribolium castaneum (red flour beetle) assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay
|
Tribolium castaneum
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality measured after 24 hr by fumigation assay
|
Rhyzopertha dominica
|
0.28
ug.mL-1
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay
|
Rhyzopertha dominica
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Rhyzopertha dominica assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay
|
Rhyzopertha dominica
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality measured after 72 hr by fumigation assay
|
Sitophilus oryzae
|
0.31
ug.mL-1
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay
|
Sitophilus oryzae
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Sitophilus oryzae (rice weevil) assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay
|
Sitophilus oryzae
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality measured after 72 hr by fumigation assay
|
Callosobruchus chinensis
|
0.17
ug.mL-1
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality at 1 ug/mL measured after 72 hr by fumigation assay
|
Callosobruchus chinensis
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Insecticidal activity against 3 to 8 days old Callosobruchus chinensis assessed as mortality at 1 ug/mL measured after 24 hr by fumigation assay
|
Callosobruchus chinensis
|
100.0
%
|
|
Journal : J Agric Food Chem
Title : Vapor-phase toxicity of Derris scandens Benth.-derived constituents against four stored-product pests.
Year : 2011
Volume : 59
Issue : 5
First Page : 1653
Last Page : 1657
Authors : Hymavathi A, Devanand P, Suresh Babu K, Sreelatha T, Pathipati UR, Madhusudana Rao J.
Abstract : The vapor-phase toxicity of Derris scandens Benth.-derived constituents was evaluated against four stored-product pests ( Callosobruchus chinensis L., Sitophilus oryzae L., Rhyzopertha dominica L., and Tribolium castaneum H.) using fumigation bioassays and compared to those of commonly used insecticides. The structures of all constituents of were characterized by spectroscopic analyses [nuclear magnetic resonance (NMR) and mass spectrometry]. The sensitivity of the test insect to compounds varied with exposure time, concentration, and insect species. Over 100% mortality after 24 h was achieved with the compounds osajin (2), scandinone (5), sphaerobioside (8), and genistein (9) against all of the test insects, while laxifolin (3) and lupalbigenin (4) showed 100% mortality after 72 h against T. csataneum and R. dominica . Scandenone (1), scandenin A (6), and scandenin (7) were less effective. Among the insects, C. chinensis , S. oryzae , and R. dominica were more susceptible to the treatments, whereas T. castaneum was less susceptible. The results of fumigation tests indicated that compounds from D. scandens whole plant extract are potential candidates to control stored-product pests.
|
Tmax in Rattus norvegicus Sprague-Dawley (rat) at 50 mg/kg, po
|
Rattus norvegicus
|
3.17
hr
|
|
Journal : Med Chem Res
Title : Intravenous pharmacokinetics and oral bioavailability of biochanin A in female rats
Year : 2011
Volume : 20
Issue : 9
First Page : 1627
Last Page : 1631
Authors : Singh SP, Wahajuddin, Jain GK
|
Cmax in Rattus norvegicus Sprague-Dawley (rat) at 5 mg/kg, iv
|
Rattus norvegicus
|
0.00833
ug.mL-1
|
|
Journal : Med Chem Res
Title : Intravenous pharmacokinetics and oral bioavailability of biochanin A in female rats
Year : 2011
Volume : 20
Issue : 9
First Page : 1627
Last Page : 1631
Authors : Singh SP, Wahajuddin, Jain GK
|
AUC (0 to t) in Rattus norvegicus Sprague-Dawley (rat) at 5 mg/kg, iv
|
Rattus norvegicus
|
94.91
hr.ng/ml
|
|
Journal : Med Chem Res
Title : Intravenous pharmacokinetics and oral bioavailability of biochanin A in female rats
Year : 2011
Volume : 20
Issue : 9
First Page : 1627
Last Page : 1631
Authors : Singh SP, Wahajuddin, Jain GK
|
Cmax in Rattus norvegicus Sprague-Dawley (rat) at 50 mg/kg, po
|
Rattus norvegicus
|
0.00833
ug.mL-1
|
|
Journal : Med Chem Res
Title : Intravenous pharmacokinetics and oral bioavailability of biochanin A in female rats
Year : 2011
Volume : 20
Issue : 9
First Page : 1627
Last Page : 1631
Authors : Singh SP, Wahajuddin, Jain GK
|
AUC (0 to t) in Rattus norvegicus Sprague-Dawley (rat) at 50 mg/kg, po
|
Rattus norvegicus
|
94.91
hr.ng/ml
|
|
Journal : Med Chem Res
Title : Intravenous pharmacokinetics and oral bioavailability of biochanin A in female rats
Year : 2011
Volume : 20
Issue : 9
First Page : 1627
Last Page : 1631
Authors : Singh SP, Wahajuddin, Jain GK
|
Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry
|
Saccharomyces cerevisiae
|
0.845
|
|
Journal : Med Chem Res
Title : Two-dimensional quantitative structureactivity relationship study on polyphenols as inhibitors of -glucosidase
Year : 2012
Volume : 21
Issue : 12
First Page : 3984
Last Page : 3993
Authors : Rastija V, Beslo D, Nikolic S
|
Growth inhibition of Homo sapiens (human) SGC7901 cells by MTT assay
|
Homo sapiens
|
5.78
uM
|
|
Journal : Med Chem Res
Title : Synthesis and cytotoxic activity of genistein derivatives
Year : 2010
Volume : 19
Issue : 9
First Page : 1296
Last Page : 1306
Authors : Zheng X, Yao X, Liu Y, Zheng Z, Cao J, Liao D
|
Growth inhibition of Homo sapiens (human) HL60 cells by MTT assay
|
Homo sapiens
|
4.82
uM
|
|
Journal : Med Chem Res
Title : Synthesis and cytotoxic activity of genistein derivatives
Year : 2010
Volume : 19
Issue : 9
First Page : 1296
Last Page : 1306
Authors : Zheng X, Yao X, Liu Y, Zheng Z, Cao J, Liao D
|
Growth inhibition of Homo sapiens (human) HT-29 cells by MTT assay
|
Homo sapiens
|
4.11
uM
|
|
Journal : Med Chem Res
Title : Synthesis and cytotoxic activity of genistein derivatives
Year : 2010
Volume : 19
Issue : 9
First Page : 1296
Last Page : 1306
Authors : Zheng X, Yao X, Liu Y, Zheng Z, Cao J, Liao D
|
Insecticidal activity against Achaea janata assessed as adult emergence at 2 ug/larva administered through topical application (Rvb = 98.8 +/- 0.5 %)
|
Achaea janata
|
27.0
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as adult emergence at 4 ug/larva administered through topical application (Rvb = 98.8 +/- 0.5 %)
|
Achaea janata
|
7.7
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as adult deformity at 2 ug/larva administered through topical application
|
Achaea janata
|
10.6
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as adult deformity at 4 ug/larva administered through topical application
|
Achaea janata
|
11.8
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as pupal mortality at 2 ug/larva administered through topical application
|
Achaea janata
|
17.2
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as pupal mortality at 4 ug/larva administered through topical application
|
Achaea janata
|
22.5
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as pupal weight at 2 ug/larva administered through topical application (Rvb = 696.4 +/- 2.6 mg)
|
Achaea janata
|
518.0
mg
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as pupal weight at 4 ug/larva administered through topical application (Rvb = 696.4 +/- 2.6 mg)
|
Achaea janata
|
532.0
mg
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as pupal duration at 2 ug/larva administered through topical application (Rvb = 10.3 +/- 0.1 days)
|
Achaea janata
|
13.1
day
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as pupal duration at 4 ug/larva administered through topical application (Rvb = 10.3 +/- 0.1 days)
|
Achaea janata
|
14.8
day
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as larval mortality at 4 ug/larva administered through topical application
|
Achaea janata
|
48.6
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as larval mortality at 2 ug/larva administered through topical application
|
Achaea janata
|
31.0
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as larval duration at 4 ug/larva administered through topical application (Rvb = 7.3 +/- 0.1 days)
|
Achaea janata
|
10.3
day
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Insecticidal activity against Achaea janata assessed as larval duration at 2 ug/larva administered through topical application (Rvb = 7.3 +/- 0.1 days)
|
Achaea janata
|
7.8
day
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Toxicity against Achaea janata at 10 ug/cm2 after 24 hr by leaf disk method
|
Achaea janata
|
100.0
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Toxicity against Achaea janata after 24 hr by leaf disk method
|
Achaea janata
|
3.29
microg/cm2
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Antifeedant activity against Achaea janata at 1 ug/cm2 by conventional no-choice disk method
|
Achaea janata
|
None
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Antifeedant activity against Achaea janata at 2 ug/cm2 by conventional no-choice disk method
|
Achaea janata
|
None
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
|
Antifeedant activity against Achaea janata by conventional no-choice disk method
|
Achaea janata
|
3.22
microg/cm2
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
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Antifeedant activity against Achaea janata at 10 ug/cm2 by conventional no-choice disk method
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Achaea janata
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97.7
%
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|
Journal : Bioorg. Med. Chem. Lett.
Title : A new benzil derivative from Derris scandens: Structure-insecticidal activity study.
Year : 2010
Volume : 20
Issue : 2
First Page : 549
Last Page : 553
Authors : Sreelatha T, Hymavathi A, Rama Subba Rao V, Devanand P, Usha Rani P, Madhusudana Rao J, Suresh Babu K.
Abstract : Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
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Relative binding affinity to ER-alpha (unknown origin) relative to estradiol
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Homo sapiens
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0.5
|
|
Journal : Med Chem Res
Title : Synthesis, structure, and estrogenic activity of 2- and 3-substituted 2,3-dihydro-4H-1-benzopyran-4-ones
Year : 2013
Volume : 22
Issue : 2
First Page : 681
Last Page : 691
Authors : Jacquot Y, Byrne C, Xicluna A, Leclercq G
