THIORIDAZINE


Synonyms	Dl-thioridazine Mellaril Mellaril-s Mellerette Melleril Novoridazine Rideril Sonapax TP-21 Thioridazine Thioridazine prolongatum Thioril
Status
Molecule Category	Free-form
ATC	N05AC02
UNII	N3D6TG58NI
EPA CompTox	DTXSID6023656


InChI Key	KLBQZWRITKRQQV-UHFFFAOYSA-N
Smiles	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2
InChI	InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

Mechanism of Action	Action	Reference
D2-like dopamine receptor antagonist	ANTAGONIST	ISBN DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	33-363.08	-	869	-
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	63.5
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor	-	2-106	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	17-65	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	2.8-85	-	8-27	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	99	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	18-60	-	70-181	-
Membrane receptor	-	2.8-85	-	70-181	-
Other cytosolic protein	-	-	-	-	85-95
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4	-	-	-	-	2.4
Transcription factor	-	-	-	-	85-95
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	21.5-26.1

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	750	-	-	63.5
Homo sapiens	-	33.2-363.08	-	8-869	21.5-95
Mus musculus	-	7.43-12.72	-	-	60
Rattus norvegicus	-	2-80	369	-	15


Protein: Serotonin 2a (5-HT2a) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468













Protein: Serotonin 2c (5-HT2c) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246

CONTENTS