CCX354

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Synonyms
Status
Molecule Category Free-form
UNII 22PQS5K5TY

Structure

InChI Key ZIMLRKWQDLVPEK-UHFFFAOYSA-N
Smiles COc1cc(N2CCN(C(=O)Cn3nc(-c4ncc[nH]4)c4cccnc43)CC2)ccc1Cl
InChI
InChI=1S/C22H22ClN7O2/c1-32-18-13-15(4-5-17(18)23)28-9-11-29(12-10-28)19(31)14-30-22-16(3-2-6-26-22)20(27-30)21-24-7-8-25-21/h2-8,13H,9-12,14H2,1H3,(H,24,25)

Pharmacology

Mechanism of Action Action Reference
C-C chemokine receptor type 1 antagonist ANTAGONIST PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CC chemokine receptor
- 2-4 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 2-4 - - -

Target Conservation

Protein: C-C chemokine receptor type 1
Description: C-C chemokine receptor type 1
Organism : Homo sapiens
P32246 ENSG00000163823

Cross References

Resources Reference
ChEMBL CHEMBL3545404
FDA SRS 22PQS5K5TY
CONTENTS