ENRASENTAN


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	GLCKXJLCYIJMRB-UPRLRBBYSA-N
Smiles	CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2
InChI	InChI=1S/C29H30O8/c1-3-11-34-19-6-7-20-22(14-19)27(21-8-5-18(33-2)15-24(21)35-12-10-30)28(29(31)32)26(20)17-4-9-23-25(13-17)37-16-36-23/h4-9,13-15,26-28,30H,3,10-12,16H2,1-2H3,(H,31,32)/t26-,27+,28+/m0/s1

Mechanism of Action	Action	Reference
Endothelin receptor ET-A antagonist	ANTAGONIST	PubMed


Protein: Endothelin receptor ET-B Description: Endothelin receptor type B Organism : Homo sapiens P24530 ENSG00000136160











Protein: Endothelin receptor ET-A Description: Endothelin-1 receptor Organism : Homo sapiens P25101 ENSG00000151617

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Endothelin receptor	-	-	-	1-1	-

Assay Description	Organism	Bioactivity
Ability to displace endothelin ([125I]ET1) from human Endothelin B receptor	None	110.0 nM
Tested for binding affinity for human Endothelin B receptor by measuring its ability to displace [125I]-ET-3 from chinese hamster ovary cells(CHO)	None	111.0 nM
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptor	None	1.1 nM
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)	None	1.1 nM

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