EcoDrugPlus


Synonyms	Acoziborole SCTX-7158 SCYX-7158 Scyx-7158
Status
Molecule Category	Free-form
UNII	2IOR2OO3GW

Synonyms

Acoziborole

SCTX-7158

SCYX-7158

Scyx-7158

Status

Molecule Category

Free-form

UNII

2IOR2OO3GW


InChI Key	PTYGDEXEGLDNAZ-UHFFFAOYSA-N
Smiles	CC1(C)OB(O)c2cc(NC(=O)c3ccc(F)cc3C(F)(F)F)ccc21
InChI	InChI=1S/C17H14BF4NO3/c1-16(2)12-6-4-10(8-14(12)18(25)26-16)23-15(24)11-5-3-9(19)7-13(11)17(20,21)22/h3-8,25H,1-2H3,(H,23,24)

InChI Key

PTYGDEXEGLDNAZ-UHFFFAOYSA-N

Smiles

CC1(C)OB(O)c2cc(NC(=O)c3ccc(F)cc3C(F)(F)F)ccc21

InChI

InChI=1S/C17H14BF4NO3/c1-16(2)12-6-4-10(8-14(12)18(25)26-16)23-15(24)11-5-3-9(19)7-13(11)17(20,21)22/h3-8,25H,1-2H3,(H,23,24)

Property Name	Value
Molecular Formula	C17H14BF4NO3
Molecular Weight	367.11

Property Name

Value

Molecular Formula

C17H14BF4NO3

Molecular Weight

367.11

Mechanism of Action	Action	Reference
Cleavage and polyadenylation specificity factor subunit inhibitor	INHIBITOR	PubMed

Mechanism of Action

Action

Reference

Cleavage and polyadenylation specificity factor subunit inhibitor

INHIBITOR

PubMed

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Trypanosoma brucei brucei	290-795	556	-	-	-

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Trypanosoma brucei brucei

290-795

556

Resources	Reference
ChEMBL	CHEMBL2347704
DrugBank	DB13086
FDA SRS	2IOR2OO3GW
PubChem	44178354
SureChEMBL	SCHEMBL1164186
ZINC	ZINC000198072921

Resources

Reference

ChEMBL

DrugBank

FDA SRS

PubChem

SureChEMBL

ZINC

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

ACOZIBOROLE

Structure

Physicochemical Descriptors

Pharmacology

Cross References