ETALOCIB


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	YFIZRWPXUYFCSN-UHFFFAOYSA-N
Smiles	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Oc1ccccc1C(=O)O
InChI	InChI=1S/C33H33FO6/c1-3-9-25-29(12-7-13-30(25)40-31-11-6-5-10-26(31)33(36)37)38-18-8-19-39-32-21-28(35)27(20-22(32)4-2)23-14-16-24(34)17-15-23/h5-7,10-17,20-21,35H,3-4,8-9,18-19H2,1-2H3,(H,36,37)

Mechanism of Action	Action	Reference
Leukotriene B4 receptor 1 antagonist	ANTAGONIST	PubMed Wikipedia DOI


Protein: Peroxisome proliferator-activated receptor gamma Description: Peroxisome proliferator-activated receptor gamma Organism : Homo sapiens P37231 ENSG00000132170











Protein: Leukotriene B4 receptor 1 Description: Leukotriene B4 receptor 1 Organism : Homo sapiens Q15722 ENSG00000213903

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Leukotriene receptor	-	3	-	7-17	-

Assay Description	Organism	Bioactivity
Compound was tested in vitro inhibitory activity against LTB4 induced Ca mobilization	Homo sapiens	20.0 nM
Compound was tested in vitro inhibitory activity against human neutrophil CD11b/CD18.	Homo sapiens	3.9 nM
Inhibition of LTB4 induced expression of human neutrophil integrin CD11b/CD18.	None	3.3 nM
Binding affinity towards Leukotriene B4 receptor guinea pig lung membrane using [3H]LTB4 as radioligand	Cavia porcellus	6.6 nM
Binding affinity towards human LTB4 receptor measured as inhibition of binding of [3H]LTB4 to isolated human neutrophils	None	17.0 nM
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	None	25.0 nM

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