MEPAZINE


Synonyms	III-2318 Lacumin Mepasin Mepazin Mepazine base Meprazine Mesapin Nothiazine P-391 Pacatal Pacatal base Pacatol Pakatal Paxital Pecatal
Status
Molecule Category	Free-form
UNII	PH34873A38
EPA CompTox	DTXSID2046177


InChI Key	CBHCDHNUZWWAPP-UHFFFAOYSA-N
Smiles	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1
InChI	InChI=1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3

Property Name	Value
Molecular Formula	C19H22N2S
Molecular Weight	310.47
AlogP	4.63
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	2.0
Polar Surface Area	6.48
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	22.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	420-830	-	-	-
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase PIM family	-	-	-	-	34

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	420-830	-	-	34

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	135324
ChEMBL	CHEMBL395110
DrugCentral	1688
FDA SRS	PH34873A38
Guide to Pharmacology	9782
SureChEMBL	SCHEMBL149976

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

MEPAZINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References