INDOPROFEN


Synonyms	Bor-ind Flosin Flosint Indoprofen Isindone K 4277 K-4277 NSC-757065 Praxis Reumofene
Status
Molecule Category	UNKNOWN
ATC	M01AE10
UNII	CPE46ZU14N
EPA CompTox	DTXSID5045831


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	RJMIEHBSYVWVIN-UHFFFAOYSA-N
Smiles	CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1
InChI	InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303











Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Auxiliary transport protein Fatty acid binding protein family	-	-	-	1270	-
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor	-	-	-	-	56
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	96

Assay Description	Organism	Bioactivity
In vitro inhibitory activity against ovine cyclooxygenase-1 (COX-1) at 200 uM; Inactive	None	50.0 %
Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M	Mus musculus	99.0 %
Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M	Homo sapiens	56.0 %
Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay	Homo sapiens	50.0 %
Inhibition of CXCL1-induced cell migration human PMN cells at 0.1 uM chemotaxis assay	Homo sapiens	40.0 %
Displacement of [125I]TZDM from beta amyloid 42 fibril	None	0.52 nM
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	Cricetulus griseus	97.2 %
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	Cricetulus griseus	96.18 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	12.29 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.04 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.04 %

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