E-7090

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Synonyms
Status
Molecule Category Free-form
UNII TN7CUD1NGA

Structure

InChI Key IBHOLSBDZMIPPT-UHFFFAOYSA-N
Smiles CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCOC)cc21
InChI
InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)

Physicochemical Descriptors

Property Name Value
Molecular Formula C32H37N5O6
Molecular Weight 587.68
AlogP 4.47
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 11.0
Polar Surface Area 127.18
Molecular species BASE
Aromatic Rings 4.0
Heavy Atoms 43.0

Pharmacology

Mechanism of Action Action Reference
Fibroblast growth factor receptor 1 inhibitor INHIBITOR PubMed PubMed

Target Conservation

Protein: Fibroblast growth factor receptor 1
Description: Fibroblast growth factor receptor 1
Organism : Homo sapiens
P11362 ENSG00000077782
Protein: Fibroblast growth factor receptor 2
Description: Fibroblast growth factor receptor 2
Organism : Homo sapiens
P21802 ENSG00000066468
Protein: Fibroblast growth factor receptor 3
Description: Fibroblast growth factor receptor 3
Organism : Homo sapiens
P22607 ENSG00000068078

Cross References

Resources Reference
ChEMBL CHEMBL3686884
FDA SRS TN7CUD1NGA
SureChEMBL SCHEMBL15955142
ZINC ZINC000169711512
CONTENTS