MARDEPODECT

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Search structure


Synonyms	MP-10 Mardepodect PF-02545920 PF-2545920
Status
Molecule Category	Free-form
UNII	R9Y8EY0G42

Structure


InChI Key	AZEXWHKOMMASPA-UHFFFAOYSA-N
Smiles	Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4ccccc4n3)cc2)n1
InChI	InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H20N4O
Molecular Weight	392.46
AlogP	5.28
Hydrogen Bond Acceptor	5.0
Number of Rotational Bond	5.0
Polar Surface Area	52.83
Molecular species	NEUTRAL
Aromatic Rings	5.0
Heavy Atoms	30.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 10 Phosphodiesterase 10A	-	0.18-2.6	-	0.17	-
Other cytosolic protein	-	-	150-290	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.18-91	150-290	-	-
Mus musculus	-	-	-	-	40-50
Rattus norvegicus	-	0.18-0.6457	-	0.17	-

Cross References

Resources	Reference
ChEMBL	CHEMBL562318
DrugBank	DB08387
FDA SRS	R9Y8EY0G42
Guide to Pharmacology	9617
PDB	PF9
PubChem	11581936
SureChEMBL	SCHEMBL1414700
ZINC	ZINC000035859742

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025