FLUFENAMIC ACID

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
ATC M01AG03
UNII 60GCX7Y6BH
EPA CompTox DTXSID7023063

Structure

InChI Key LPEPZBJOKDYZAD-UHFFFAOYSA-N
Smiles O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1
InChI
InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H10F3NO2
Molecular Weight 281.23
AlogP 4.15
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 49.33
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 20.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Oxidoreductase
- 16-760 - - -0.1-70
Enzyme
- 16-760 - - -0.1-70
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 26.7
Secreted protein
- - 30 - 98
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4
- - - - 42
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 64.03-211.28
Transporter Primary active transporter Oxidoreduction-driven transporters
- - - - 18
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cavia porcellus
- - - - 26.7
Cricetulus griseus
- - - - 64.03-211.28
Homo sapiens
- 410-760 30-109 - 18-98
Oryctolagus cuniculus
- - - - 5-50
Rattus norvegicus
- - - - 19-64.4

Related Entries

Environmental Exposure

Environmental Exposure Map
Countries
Germany
Hungary
Romania
Serbia

Cross References

Resources Reference
ChEBI 42638
ChEMBL CHEMBL23588
DrugBank DB02266
DrugCentral 1193
FDA SRS 60GCX7Y6BH
Guide to Pharmacology 2447
KEGG C13038
PDB FLF
PharmGKB PA166049190
PubChem 3371
SureChEMBL SCHEMBL17497
ZINC ZINC000000086535
CONTENTS