EcoDrugPlus


Synonyms	.delta.9-tetrahydrocannabivarin GWP-42004 GWP42004 Gwp42004 O-4394 THCV Tetrahydrocannabivarin Thc-v
Status
Molecule Category	Free-form
UNII	I5YE3I47D8
EPA CompTox	DTXSID10893920


InChI Key	ZROLHBHDLIHEMS-HUUCEWRRSA-N
Smiles	CCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21
InChI	InChI=1S/C19H26O2/c1-5-6-13-10-16(20)18-14-9-12(2)7-8-15(14)19(3,4)21-17(18)11-13/h9-11,14-15,20H,5-8H2,1-4H3/t14-,15-/m1/s1

Property Name	Value
Molecular Formula	C19H26O2
Molecular Weight	286.42
AlogP	4.96
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	29.46
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	21.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Cannabinoid receptor	-	13.1-17.6	-	1.5-75.4	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	13.1-17.6	-	1.5-75.4	-
Mus musculus	-	-	-	75.4	-

Resources	Reference
ChEMBL	CHEMBL2387541
DrugBank	DB11755
FDA SRS	I5YE3I47D8
Guide to Pharmacology	6418
PubChem	93147
SureChEMBL	SCHEMBL6856739
ZINC	ZINC000005649505

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

TETRAHYDROCANNABIVARIN

Structure

Physicochemical Descriptors

Pharmacology

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