(D)-SERINE

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Synonyms
Status
Molecule Category UNKNOWN
UNII 1K77H2Z9B1
EPA CompTox DTXSID9041021

Structure

InChI Key MTCFGRXMJLQNBG-UWTATZPHSA-N
Smiles N[C@H](CO)C(=O)O
InChI
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C3H7NO3
Molecular Weight 105.09
AlogP -1.61
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 2.0
Polar Surface Area 83.55
Molecular species ZWITTERION
Aromatic Rings 0.0
Heavy Atoms 7.0
Assay Description Organism Bioactivity Reference
In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptor None 670.0 nM
Compound was evaluated for in vitro inhibition of [3H]TCP at NMDA receptor None 200.0 nM
In vitro concentration eliciting half-maximal effect on [3H]-MK 801 radioligand binding to NMDA receptor None 160.0 nM
In vitro inhibition of [3H]glycine at NMDA receptor None 300.0 nM
Effective concentration against NR1/NR2A receptor None 320.0 nM
Effective concentration against NR1/NR2B receptor None 260.0 nM
Effective concentration against NR1/NR2C receptor None 210.0 nM
Effective concentration against NR1/NR2D receptor None 170.0 nM
Displacement of [3H]glycine from strychnine-insensitive glycine recognition site of NMDA receptor in rat brain cortex membrane Rattus norvegicus 316.23 nM
Inhibition of ASCT2 mediated [3H]-D-serine uptake in rat hippocampal astrocytes at 1 mM after 5 mins by beta counting analysis Rattus norvegicus 25.0 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Homo sapiens 7.43 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 26.21 % SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 12.9 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.09 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.1 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.09 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.1 %
Agonist activity at rat GluN1/GluN2B NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay Rattus norvegicus 620.0 nM
Agonist activity at rat GluN1/GluN2C NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay Rattus norvegicus 190.0 nM
Agonist activity at rat GluN1/GluN2D NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay Rattus norvegicus 150.0 nM

Cross References

Resources Reference
ChEBI 16523
ChEMBL CHEMBL285123
DrugBank DB03929
FDA SRS 1K77H2Z9B1
Human Metabolome Database HMDB0003406
Guide to Pharmacology 4171
KEGG C00740
PDB DSN
SureChEMBL SCHEMBL43094
ZINC ZINC000000895342
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