TENOFOVIR EXALIDEX

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Synonyms
Status
Molecule Category Free-form
UNII K7J545MEMA

Structure

InChI Key SCTJKHUUZLXJIP-RUZDIDTESA-N
Smiles CCCCCCCCCCCCCCCCOCCCOP(=O)(O)CO[C@H](C)Cn1cnc2c(N)ncnc21
InChI
InChI=1S/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C28H52N5O5P
Molecular Weight 569.73
AlogP 6.86
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 25.0
Polar Surface Area 134.61
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 39.0

Pharmacology

Mechanism of Action Action Reference
Human immunodeficiency virus type 1 reverse transcriptase inhibitor INHIBITOR PubMed
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Hepatitis B virus
490 - - - -
Human immunodeficiency virus 1
0.66-57 - - - -
Human immunodeficiency virus 2
3.5-3.5 - - - -
Human immunodeficiency virus type 1 (JRCSF ISOLATE)
1.1-16 - - - -

Related Entries

Cross References

Resources Reference
ChEMBL CHEMBL515564
DrugBank DB14925
FDA SRS K7J545MEMA
PubChem 23628250
SureChEMBL SCHEMBL2299893
ZINC ZINC000042875215
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