Inhibition of hepatitis C virus in a cell based HCV replicon assay.
|
Hepatitis C virus
|
1.2
nM
|
|
Inhibitory concentration against hepatitis C virus NS3 protease
|
Hepatitis C virus
|
3.0
nM
|
|
Inhibition of HCV 1b NS3 protease
|
Hepatitis C virus subtype 1b
|
0.66
nM
|
|
Inhibition of HCV 1a NS3 protease
|
Hepatitis C virus subtype 1a
|
0.3
nM
|
|
Antiviral activity against HCV 1b-N
|
Hepatitis C virus subtype 1b
|
4.0
nM
|
|
Inhibition of HCV NS3 protease by FRET assay
|
Hepatitis C virus
|
0.66
nM
|
|
Antiviral activity against Hepatitis C virus infected human hepatoma cells by replicon assay
|
Hepatitis C virus
|
3.0
nM
|
|
Inhibition of HCV NS3-4A protease
|
Hepatitis C virus
|
3.0
nM
|
|
Antiviral activity against HCV replicon
|
Hepatitis C virus
|
1.2
nM
|
|
Inhibition of full length HCV NS3/4A protease
|
Hepatitis C virus
|
0.3
nM
|
|
Inhibition of HCV replication in human HuH7-Rep cells containing subgenomic bicistronic clone
|
Hepatitis C virus
|
1.63
nM
|
|
Antiviral activity against HCV 1a containing chimeric genotype 1a-H77/1b-con1 subgenom in human Huh7 cells assessed as reduction in viral RNA after 7 days by RT-PCR
|
Hepatitis C virus subtype 1a
|
3.0
nM
|
|
Antiviral activity against HCV isolate Con1 in human Huh7 cells assessed as reduction in viral RNA after 7 days by RT-PCR
|
Hepatitis C virus (isolate Con1)
|
3.0
nM
|
|
Antiviral activity against wild type HCV 1b strain N infected in chimpanzee
|
Hepatitis C virus subtype 1b
|
1.4
nM
|
|
Antiviral activity against HCV 1b strain N with NS5B polymerase C316Y mutation infected in chimpanzee measured on day 2
|
Hepatitis C virus subtype 1b
|
1.3
nM
|
|
Antiviral activity against HCV 1b strain N with NS5B polymerase C316Y mutation infected in chimpanzee measured on day 5
|
Hepatitis C virus subtype 1b
|
1.3
nM
|
|
Antiviral activity against HCV 1b strain N with NS5B polymerase C316Y mutation infected in chimpanzee measured on day 11
|
Hepatitis C virus subtype 1b
|
1.1
nM
|
|
Antiviral activity against HCV 1b strain N with NS5B polymerase C316Y mutation infected in chimpanzee measured on day 28
|
Hepatitis C virus subtype 1b
|
1.3
nM
|
|
Antiviral activity against HCV 1a H77 with NS5B polymerase G554D mutation infected in chimpanzee measured on day 2
|
Hepatitis C virus (isolate H77)
|
2.7
nM
|
|
Antiviral activity against HCV 1a H77 with NS5B polymerase G554D mutation infected in chimpanzee measured on day 5
|
Hepatitis C virus (isolate H77)
|
3.1
nM
|
|
Antiviral activity against HCV 1a H77 with NS5B polymerase G554D mutation infected in chimpanzee measured on day 16
|
Hepatitis C virus (isolate H77)
|
2.8
nM
|
|
Antiviral activity against HCV 1a H77 with NS5B polymerase Y448C mutation infected in chimpanzee measured on day 28
|
Hepatitis C virus (isolate H77)
|
3.3
nM
|
|
Antiviral activity against HCV2a J6/JFH1 infected in Huh7-5 cells at early T1 stage assessed as inhibition of core protein dimerization by RT PCR
|
Hepatitis C virus subtype 2a
|
72.0
nM
|
|
Antiviral activity against HCV2a J6/JFH1 infected in Huh7-5 cells at late T2 stage assessed as inhibition of core protein dimerization by RT PCR
|
Hepatitis C virus subtype 2a
|
71.0
nM
|
|
Inhibition of HCV NS3 protease by FRET assay
|
Hepatitis C virus
|
0.3
nM
|
|
Antiviral activity against HCV 1B infected in human Huh7 cells by firefly luciferase reporter gene assay
|
Hepatitis C virus subtype 1b
|
4.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 2a infected in mouse HB1 cell by cell-based HCV replicon assay in presence of 10% fetal bovine serum
|
Hepatitis C virus subtype 2a
|
27.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b infected in mouse HB1 cell by cell-based HCV replicon assay in presence of 50% normal human serum
|
Hepatitis C virus subtype 1b
|
17.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b infected in mouse HB1 cell by cell-based HCV replicon assay in presence of 10% fetal bovine serum
|
Hepatitis C virus subtype 1b
|
3.0
nM
|
|
Inhibition of Hepatitis C virus genotype 2b NS3/4A protease activity
|
Hepatitis C virus subtype 2b
|
61.0
nM
|
|
Inhibition of Hepatitis C virus genotype 2a NS3/4A protease activity
|
Hepatitis C virus subtype 2a
|
7.0
nM
|
|
Inhibition of Hepatitis C virus genotype 1b NS3/4A protease activity
|
Hepatitis C virus subtype 1b
|
0.3
nM
|
|
Inhibition of Hepatitis C virus genotype 1a NS3/4A protease activity
|
Hepatitis C virus subtype 1a
|
0.81
nM
|
|
Inhibition of HCV NS3 protease
|
Hepatitis C virus
|
3.0
nM
|
|
Antiviral activity against HCV Con1 by cell based-luciferase reporter gene assay
|
Hepatitis C virus
|
2.0
nM
|
|
Antiviral activity against wild-type Hepatitis C virus genotype 1b N infected in human Huh7 cells
|
Hepatitis C virus subtype 1b
|
1.5
nM
|
|
Antiviral activity against cyclosporine A/NIM811-resistant HCV subtype 1b Con1 infected in human HuH7 cells assessed as reduction in viral RNA level after 48 hrs by qRT-PCR analysis
|
Hepatitis C virus
|
1.5
nM
|
|
Antiviral activity against HCV subtype 1b Con1 infected in human HuH7 cells assessed as reduction in viral RNA level after 48 hrs by qRT-PCR analysis
|
Hepatitis C virus
|
1.4
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b in luciferase encoding genotype 1b replicons after 3 days by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
3.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1a in luciferase encoding genotype 1a replicons after 3 days by luciferase reporter assay
|
Hepatitis C virus subtype 1a
|
17.0
nM
|
|
Antiviral activity against compound-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR
|
Hepatitis C virus subtype 1b
|
100.0
nM
|
|
Antiviral activity against cyclosporine-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR
|
Hepatitis C virus subtype 1b
|
170.0
nM
|
|
Antiviral activity against 2'-C-methyl-2'-fluoro-cytidine-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR
|
Hepatitis C virus subtype 1b
|
290.0
nM
|
|
Antiviral activity against VX 950-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR
|
Hepatitis C virus subtype 1b
|
310.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh5-2 cells assessed as reduction in replicon RNA after 4 days by luciferase assay
|
Hepatitis C virus subtype 1b
|
40.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh-9-13 cells assessed as reduction in replicon RNA after 4days by RT-qPCR analysis
|
Hepatitis C virus subtype 1b
|
15.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH6 cells assessed as reduction in replicon RNA after 4days by RT-qPCR analysis
|
Hepatitis C virus subtype 1b
|
4.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh-Mono cells assessed as reduction in replicon RNA after 4 days by RT-qPCR analysis
|
Hepatitis C virus subtype 1b
|
10.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing WT NS3 infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.8
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 V36L mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
1.4
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 V36M mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
2.4
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 V36A mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q41R mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
2.3
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 F43S mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 F43I mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.4
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 F43V mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.4
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 T54A mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.7
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 T54S mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.9
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80R mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
1.4
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80H mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
1.2
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80K mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80G mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
3.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80L mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.8
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 R109K mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
1.4
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 S138T mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.5
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 R155M mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
84.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 R155I mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
29.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 R155Q mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
248.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 R155T mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
685.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 R155K mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
489.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 A156S mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
1.7
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 A156G mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
22.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 D168G mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
35.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 D168N mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
18.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 D168E mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
40.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 D168T mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
520.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 D168H mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
215.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 D168A mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
304.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 V170T mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
4.8
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 V170A mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.8
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 F43S and Q80R mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
0.4
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 F43S and D168E mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
5.8
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80K and R155K mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
705.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80R and R155K mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
707.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80R and D168E mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
87.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b expressing NS3 Q80H and D168E mutant infected in HuH7 cells after 48 hrs by by luciferase reporter assay
|
Hepatitis C virus subtype 1b
|
52.0
nM
|
|
Antiviral activity against Hepatitis C virus JFH-1 J6 infected in human HuH7.5 cells assessed as inhibition of virus propagation measured after 72 hrs
|
Hepatitis C virus JFH-1
|
72.0
nM
|
|
Antiviral activity against Hepatitis C virus JFH-1 J6 infected in human HuH7.5 cells assessed as inhibition of virus propagation measured after 72 hrs of transfer to fresh media
|
Hepatitis C virus JFH-1
|
71.0
nM
|
|
Antiviral activity against HCV genotype 1b infected in Huh7 cells assessed as inhibition of viral replication by cell-based replicon assay
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Inhibition of HCV 1a NS3/4A protease
|
Hepatitis C virus subtype 1a
|
1.0
nM
|
|
Antiviral activity against HCV
|
Hepatitis C virus
|
350.0
nM
|
|
Inhibition of HCV NS3 protease
|
Hepatitis C virus
|
40.0
nM
|
|
Inhibition of HCV1b NS3/4A protease
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Antiviral activity against HCV genotype 1b infected in human Huh cells expressing luc gene by replicon assay
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Inhibition of Hepatitis C virus genotype 1b NS3/4A protease
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh cells by luciferase reporter gene based replicon assay
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Inhibition of HCV 1a protease 1a domain
|
Hepatitis C virus
|
2.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b by stable replicon assay
|
Hepatitis C virus subtype 1b
|
0.5
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1a by stable replicon assay
|
Hepatitis C virus subtype 1a
|
2.2
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b harboring protease D168V mutant by transient replicon assay
|
Hepatitis C virus subtype 1b
|
438.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b harboring protease D168A mutant by transient replicon assay
|
Hepatitis C virus subtype 1b
|
205.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b harboring protease A156V mutant by transient replicon assay
|
Hepatitis C virus subtype 1b
|
627.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b harboring protease A156T mutant by transient replicon assay
|
Hepatitis C virus subtype 1b
|
604.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b harboring protease A156S mutant by transient replicon assay
|
Hepatitis C virus subtype 1b
|
3.0
nM
|
|
Antiviral activity against wild type Hepatitis C virus subtype 1b by transient replicon assay
|
Hepatitis C virus subtype 1b
|
1.0
nM
|
|
Antiviral activity against Hepatitis C virus subtype 1b harboring protease R155K mutant by transient replicon assay
|
Hepatitis C virus subtype 1b
|
241.0
nM
|
|
Antiviral activity against HCV1b by cell based replicon assay
|
Hepatitis C virus subtype 1b
|
4.0
nM
|
|
Antiviral activity against HCV1a by cell based replicon assay
|
Hepatitis C virus subtype 1a
|
3.0
nM
|
|
Inhibition of HCV 1a NS3 protease
|
Hepatitis C virus subtype 1a
|
0.3
nM
|
|
Inhibition of HCV 1b NS3 protease
|
Hepatitis C virus subtype 1b
|
0.66
nM
|
|
Inhibition of Hepatitis C virus genotype 3a full-length NS3 protease assessed as overall/observed affinity by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 3a
|
160.0
nM
|
|
Inhibition of Hepatitis C virus genotype 1b NS3 protease domain assessed as overall/observed affinity by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1b
|
2.5
nM
|
|
Inhibition of Hepatitis C virus genotype 1b full-length NS3/NS4A protease assessed as overall/observed affinity by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1b
|
71.0
nM
|
|
Inhibition of Hepatitis C virus genotype 1b full-length NS3 protease assessed as overall/observed affinity by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1b
|
67.0
nM
|
|
Inhibition of Hepatitis C virus genotype 1a full-length NS3/NS4A protease assessed as overall/observed affinity by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1a
|
2.1
nM
|
|
Inhibition of Hepatitis C virus genotype 1a full-length NS3 protease assessed as overall/observed affinity by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1a
|
1.3
nM
|
|
Inhibition of Hepatitis C virus genotype 1b NS3 protease domain assessed as equilibrium dissociation constant by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1b
|
7.3
nM
|
|
Inhibition of Hepatitis C virus genotype 1b full-length NS3/NS4A protease assessed as equilibrium dissociation constant by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1b
|
71.0
nM
|
|
Inhibition of Hepatitis C virus genotype 1b full-length NS3 protease assessed as equilibrium dissociation constant by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1b
|
220.0
nM
|
|
Inhibition of Hepatitis C virus genotype 1a full-length NS3/NS4A protease assessed as equilibrium dissociation constant by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1a
|
2.1
nM
|
|
Inhibition of Hepatitis C virus genotype 1a full-length NS3 protease assessed as equilibrium dissociation constant by surface plasmon resonance biosensor-based interaction kinetic analysis
|
Hepatitis C virus subtype 1a
|
3.0
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells by subgenomic replicon-based luciferase assay
|
Hepatitis C virus subtype 1b
|
4.0
nM
|
|
Inhibition of Hepatitis C virus genotype 1a full length NS3/2K-NS4A protease using Ac-DED(Edans)EEAbupsi[COO]ASK(Dabcyl)-NH2 as substrate incubated for 10 mins prior to substrate addition by FRET analysis
|
Hepatitis C virus subtype 1a
|
0.3
nM
|
|
Inhibition of full-length HCV NS3 protease R155K mutant
|
Hepatitis C virus
|
24.0
nM
|
|
Inhibition of full-length HCV NS3 protease D168V mutant
|
Hepatitis C virus
|
200.0
nM
|
|
Inhibition of full-length HCV NS3 protease A156T mutant
|
Hepatitis C virus
|
120.0
nM
|
|
Inhibition of full-length wild-type HCV NS3 protease
|
Hepatitis C virus
|
0.089
nM
|
|
Inhibition of HCV genotype 1a NS3/4A protease using Ac-DED(Edans)EEAbu-psi[COO]ASK(Dabcyl)-NH2 as substrate by FRET assay
|
Hepatitis C virus subtype 1a
|
0.3
nM
|
|
Antiviral activity against HCV genotype 1a
|
Hepatitis C virus subtype 1a
|
4.0
nM
|
|
Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assay
|
Hepatitis C virus (isolate Con1)
|
0.8
nM
|
|
Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human Huh7 cells assessed as inhibition of NS4A expression by ELISA
|
Hepatitis C virus (isolate Con1)
|
2.8
nM
|
|
Inhibition of full length HCV 1b Con1 NS3/4A protease using HiLyte Fluor 610 peptide substrate by biochemical FRET assay
|
Hepatitis C virus (isolate Con1)
|
0.9
nM
|
|
Antiviral activity against HCV Con1 infected in human GS4.1 cells containing HCV Con1 subgenomic replicon assessed as reduction in NS5A protein expression by ELISA method
|
Hepatitis C virus (isolate Con1)
|
2.8
nM
|
|
Inhibition of HCV genotype-3a full length NS3 protease preincubated for 10 mins followed by Ac-DED(Edans)EEAbuj-[COO]ASK(Dabcyl)-NH2 addition in presence of co-factor 2K-NS4A by fluorescence assay
|
Hepatitis C virus subtype 3a
|
20.0
nM
|
|
Inhibition of HCV genotype-1a NS3 protease
|
Hepatitis C virus subtype 1a
|
0.089
nM
|
|
Antiviral activity against HCV genotype 1b infected in human HuH7 cells
|
Hepatitis C virus subtype 1b
|
2.0
nM
|
|
Antiviral activity against HCV
|
Hepatitis C virus
|
9.5
nM
|
|