TRAMIPROSATE

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Search structure


Synonyms	3-aminopropane sulfonic acid Acamprosate related compound a NC-758 NSC-77071 Tramiprosate
Status
Molecule Category	Free-form
UNII	5K8EAX0G53
EPA CompTox	DTXSID80190352

Structure


InChI Key	SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Smiles	NCCCS(=O)(=O)O
InChI	InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C3H9NO3S
Molecular Weight	139.18
AlogP	-0.78
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	80.39
Molecular species	ZWITTERION
Aromatic Rings	0.0
Heavy Atoms	8.0

Pharmacology

Mechanism of Action	Action	Reference
Beta amyloid A4 protein stabiliser	STABILISER	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel GABA-A receptor	-	300	-	-	-
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	-	-	-	18

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	18
Rattus norvegicus	-	300	-	-	-

Target Conservation


Protein: Beta amyloid A4 protein Description: Amyloid-beta precursor protein Organism : Homo sapiens P05067 ENSG00000142192

Cross References

Resources	Reference
ChEBI	1457
ChEMBL	CHEMBL149082
DrugBank	DB06527
FDA SRS	5K8EAX0G53
KEGG	C03349
PDB	A20
PubChem	1646
SureChEMBL	SCHEMBL26759
ZINC	ZINC000001529636

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025