ZOTIRACICLIB


Synonyms	EX45 Ex 45 SB-1317 SB1317 Sb-1317 free base TG02 Tg-02 Tg02 Zotiraciclib
Status
Molecule Category	Free-form
UNII	40D08182TT


InChI Key	VXBAJLGYBMTJCY-NSCUHMNNSA-N
Smiles	CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1
InChI	InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+

Mechanism of Action	Action	Reference
Cyclin-dependent kinase 1 inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6	-	950	-	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDC2 subfamily	-	3-130	-	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK5 subfamily	-	3-4	-	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK7 subfamily	-	3-37	-	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK9 subfamily	-	2-3	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakA family	-	73-170	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakB family	-	73-170	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	21-56	-	-	-
Enzyme Kinase Protein kinase regulatory subunit	-	3-4	-	-	-
Other cytosolic protein	-	3-37	-	-	-
Unclassified protein	-	3-37	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	2-950	-	-	-


Protein: Tyrosine-protein kinase JAK2 Description: Tyrosine-protein kinase JAK2 Organism : Homo sapiens O60674 ENSG00000096968











Protein: Cyclin-dependent kinase 1 Description: Cyclin-dependent kinase 1 Organism : Homo sapiens P06493 ENSG00000170312














Protein: Cyclin-dependent kinase 2 Description: Cyclin-dependent kinase 2 Organism : Homo sapiens P24941 ENSG00000123374












Protein: Tyrosine-protein kinase receptor FLT3 Description: Receptor-type tyrosine-protein kinase FLT3 Organism : Homo sapiens P36888 ENSG00000122025











Protein: Cyclin-dependent kinase 7 Description: Cyclin-dependent kinase 7 Organism : Homo sapiens P50613 ENSG00000134058














Protein: Cyclin-dependent kinase 9 Description: Cyclin-dependent kinase 9 Organism : Homo sapiens P50750 ENSG00000136807

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