MANIDIPINE 6300


Synonyms	Artedil Franidipine Manidipine Manidipine 6300 Manidipine hydrochloride
Status
Molecule Category	UNKNOWN
UNII	6O4754US88
EPA CompTox	DTXSID2043745


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	ANEBWFXPVPTEET-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1
InChI	InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3

Mechanism of Action	Action	Reference
Voltage-gated L-type calcium channel blocker	BLOCKER	Other Other PubMed


Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1F Organism : Homo sapiens O60840 ENSG00000102001











Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1D Organism : Homo sapiens Q01668 ENSG00000157388











Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1S Organism : Homo sapiens Q13698 ENSG00000081248











Protein: Voltage-gated L-type calcium channel Description: Voltage-dependent L-type calcium channel subunit alpha-1C Organism : Homo sapiens Q13936 ENSG00000151067

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Cysteine protease Cysteine protease CA clan Cysteine protease C1A family	-	6000	-	-	-

Assay Description	Organism	Bioactivity
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	5.3 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	6.71 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.85 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.85 %

CONTENTS