EcoDrugPlus


Synonyms	AR67 Ar-67 DB 67 DB-67 NSC-708298 Silatecan
Status
Molecule Category	Free-form
UNII	3YEA04NV6H
EPA CompTox	DTXSID00176592


InChI Key	XUSKJHCMMWAAHV-SANMLTNESA-N
Smiles	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccc(O)cc1c2[Si](C)(C)C(C)(C)C
InChI	InChI=1S/C26H30N2O5Si/c1-7-26(32)18-11-20-21-16(12-28(20)23(30)17(18)13-33-24(26)31)22(34(5,6)25(2,3)4)15-10-14(29)8-9-19(15)27-21/h8-11,29,32H,7,12-13H2,1-6H3/t26-/m0/s1

Property Name	Value
Molecular Formula	C26H30N2O5Si
Molecular Weight	478.62

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	14	-	-	-
Mus musculus	-	-	-	-	61-73

Resources	Reference
ChEMBL	CHEMBL412309
DrugBank	DB12384
FDA SRS	3YEA04NV6H
Guide to Pharmacology	8919
PubChem	6712744
SureChEMBL	SCHEMBL1266162
ZINC	ZINC000170020689

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

AR-67

Structure

Physicochemical Descriptors

Pharmacology

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