HYDROXYCAMPTOTHECIN


Synonyms	(s)-10-hydroxycamptothecin 10-Hydroxy Camptothecin 10-Hydroxy-Camptothecin 10-Hydroxycamptothecine 10-hcpt 10-hydroxycamptothecin Hydroxycamptothecin Irinotecan related compound a NSC-107124
Status
Molecule Category	Free-form
UNII	9Z01632KRV


InChI Key	HAWSQZCWOQZXHI-FQEVSTJZSA-N
Smiles	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(O)ccc3nc2-1
InChI	InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

Property Name	Value
Molecular Formula	C20H16N2O5
Molecular Weight	364.36
AlogP	1.79
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	1.0
Polar Surface Area	101.65
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	27.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-	-5.24-6.63
Enzyme Isomerase	-	110	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Electrophorus electricus	-	-	-	-
Equus caballus	-	-	-	-	6.63
Homo sapiens	-	4-981	-	-	92
Mus musculus	-	12-496	-	-	36.5

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	81395
ChEMBL	CHEMBL273862
DrugBank	DB12385
FDA SRS	9Z01632KRV
KEGG	C17939
SureChEMBL	SCHEMBL25875
ZINC	ZINC000003979155

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

HYDROXYCAMPTOTHECIN

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Pharmacology

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