S-1360

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Search structure


Synonyms	GSK-S-1360 GW-810781 GW810781 Gw810781 S 1360
Status
Molecule Category	Free-form
UNII	W7KQU075CV

Structure


InChI Key	HFHDGHOGHWXXDT-ZSOIEALJSA-N
Smiles	O=C(/C=C(\O)c1nc[nH]n1)c1ccc(Cc2ccc(F)cc2)o1
InChI	InChI=1S/C16H12FN3O3/c17-11-3-1-10(2-4-11)7-12-5-6-15(23-12)13(21)8-14(22)16-18-9-19-20-16/h1-6,8-9,22H,7H2,(H,18,19,20)/b14-8-

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H12FN3O3
Molecular Weight	313.29
AlogP	2.91
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	92.01
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Human immunodeficiency virus type 1 integrase inhibitor	INHIBITOR	PubMed Other PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	20-600	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Hepatitis C virus	-	-	-	-	22.4
Human immunodeficiency virus	140-200	20-160	-	-	-
Human immunodeficiency virus 1	-	20-600	-	-	-

Cross References

Resources	Reference
ChEMBL	CHEMBL218227
DrugBank	DB16032
FDA SRS	W7KQU075CV
PubChem	6451047
SureChEMBL	SCHEMBL10070153
ZINC	ZINC000100406242

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025