EcoDrugPlus


Synonyms	Pramocaine Pramoxine
Status
Molecule Category	Free-form
UNII	068X84E056
EPA CompTox	DTXSID8040692

Synonyms

Pramocaine

Pramoxine

Status

Molecule Category

Free-form

UNII

068X84E056

EPA CompTox

DTXSID8040692


InChI Key	DQKXQSGTHWVTAD-UHFFFAOYSA-N
Smiles	CCCCOc1ccc(OCCCN2CCOCC2)cc1
InChI	InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3

InChI Key

DQKXQSGTHWVTAD-UHFFFAOYSA-N

Smiles

CCCCOc1ccc(OCCCN2CCOCC2)cc1

InChI

InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3

Property Name	Value
Molecular Formula	C17H27NO3
Molecular Weight	293.41
AlogP	2.97
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	9.0
Polar Surface Area	30.93
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	21.0

Property Name

Value

Molecular Formula

C17H27NO3

Molecular Weight

293.41

AlogP

2.97

Hydrogen Bond Acceptor

4.0

Number of Rotational Bond

9.0

Polar Surface Area

30.93

Molecular species

NEUTRAL

Aromatic Rings

1.0

Heavy Atoms

21.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	29.7-86.3

Targets

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Ion channel Voltage-gated ion channel Voltage-gated sodium channel

29.7-86.3

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	29.7-86.3

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Cavia porcellus

29.7-86.3

Resources	Reference
ChEBI	8357
ChEMBL	CHEMBL1198
DrugBank	DB09345
DrugCentral	3487
FDA SRS	068X84E056
KEGG	C07892
PDB	PX9
PubChem	4886
SureChEMBL	SCHEMBL26020
ZINC	ZINC000019594594

Resources

Reference

ChEBI

ChEMBL

DrugBank

DrugCentral

FDA SRS

KEGG

PDB

PubChem

SureChEMBL

ZINC

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

PRAMOXINE

Structure

Physicochemical Descriptors

Pharmacology

Cross References