SRT-2104

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Synonyms
Status
Molecule Category Free-form
UNII 4521NR0J09
EPA CompTox DTXSID00648729

Structure

InChI Key LAMQVIQMVKWXOC-UHFFFAOYSA-N
Smiles Cc1nc(-c2cccnc2)sc1C(=O)Nc1ccccc1-c1cn2c(CN3CCOCC3)csc2n1
InChI
InChI=1S/C26H24N6O2S2/c1-17-23(36-25(28-17)18-5-4-8-27-13-18)24(33)29-21-7-3-2-6-20(21)22-15-32-19(16-35-26(32)30-22)14-31-9-11-34-12-10-31/h2-8,13,15-16H,9-12,14H2,1H3,(H,29,33)

Physicochemical Descriptors

Property Name Value
Molecular Formula C26H24N6O2S2
Molecular Weight 516.65
AlogP 4.97
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 84.65
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 36.0

Pharmacology

Mechanism of Action Action Reference
NAD-dependent deacetylase sirtuin 1 activator ACTIVATOR PubMed PubMed PubMed

Target Conservation

Protein: NAD-dependent deacetylase sirtuin 1
Description: NAD-dependent protein deacetylase sirtuin-1
Organism : Homo sapiens
Q96EB6 ENSG00000096717

Cross References

Resources Reference
ChEMBL CHEMBL4297436
DrugBank DB12186
FDA SRS 4521NR0J09
Guide to Pharmacology 9515
PubChem 25108829
SureChEMBL SCHEMBL964014
ZINC ZINC000043202455
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