Dissociation constant with dimeric 16S rRNA RNA construct B
|
None
|
350.0
nM
|
|
Dissociation constant towards 16S rRNA construct A
|
None
|
440.0
nM
|
|
Dissociation constant towards 16S rRNA construct B
|
None
|
380.0
nM
|
|
Binding affinity of aminoglycoside to 16S ribosomal RNA A-site in Escherichia coli
|
Escherichia coli
|
19.0
nM
|
|
Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence anisotropy
|
None
|
180.0
nM
|
|
Inhibitory activity against the displacement of Picogreen from fMet-tRNA(fMet) by the aminoglycoside
|
Staphylococcus aureus
|
9.0
nM
|
|
Inhibitory activity of the aminoglycoside on Staphylococcus aureus IF-2 binding to fMet-tRNA(fMet)
|
Staphylococcus aureus
|
50.0
nM
|
|
Maximal inhibition against the displacement of Picogreen from fMet-tRNA(fMet) by the aminoglycoside
|
Staphylococcus aureus
|
100.0
%
|
|
Maximal inhibition of the aminoglycoside on Staphylococcus aureus IF-2 binding to fMet-tRNA(fMet)
|
Staphylococcus aureus
|
76.0
%
|
|
Dissociation constant for binding to mitochondrial 12S rRNA construct M2 was determined
|
Homo sapiens
|
140.0
nM
|
|
Dissociation constant for binding to mitochondrial 12S rRNA construct M3 was determined
|
Homo sapiens
|
120.0
nM
|
|
Dissociation constant for binding to mitochondrial 12S rRNA construct M4 was determined
|
Homo sapiens
|
160.0
nM
|
|
Tested for binding affinity against RNA construct A
|
None
|
410.0
nM
|
|
Tested for binding affinity against RNA construct B
|
None
|
380.0
nM
|
|
Tested for binding affinity against RNA construct D
|
None
|
470.0
nM
|
|
Tested for binding affinity against RNA construct E
|
None
|
91.0
nM
|
|
Concentration required for the inhibition of HIV- 1 Tat-derived peptide binding to TAR RNA.
|
None
|
920.0
nM
|
|
Dissociation constant of the compound
|
None
|
100.0
nM
|
|
Inhibition of anthrax lethal factor metalloprotease
|
Bacillus anthracis
|
500.0
nM
|
|
Binding affinity to Rev response element RNA
|
None
|
180.0
nM
|
|
Binding affinity to tRNA
|
None
|
370.0
nM
|
|
Binding affinity to Escherichia coli K12 stem-loop region L2-10 RNA aptamers using luminescence spectrometer by anisotropy technique
|
Escherichia coli
|
308.0
nM
|
|
Binding affinity to Escherichia coli K12 stem-loop region L2-11 RNA aptamers using luminescence spectrometer by anisotropy technique
|
Escherichia coli
|
313.0
nM
|
|
Binding affinity to Escherichia coli K12 stem-loop region L2-12 RNA aptamers using luminescence spectrometer by anisotropy technique
|
Escherichia coli
|
320.0
nM
|
|
Binding affinity to A-site RNA
|
None
|
60.0
nM
|
|
Antibacterial activity against Klebsiella pneumoniae ATCC 700603
|
Klebsiella pneumoniae
|
0.6
ug.mL-1
|
|
Inhibition of protein synthesis in Pseudomonas aeruginosa ATCC 27853 assessed as decrease in incorporation of L-[4,5-3H]leucine at MIC by liquid scintillation counter relative to control
|
Pseudomonas aeruginosa
|
40.0
%
|
|
Inhibition of protein synthesis in Pseudomonas aeruginosa ATCC 27853 assessed as decrease in incorporation of L-[4,5-3H]leucine at 10 times MIC by liquid scintillation counter relative to control
|
Pseudomonas aeruginosa
|
40.0
%
|
|
Binding affinity to RNA by RNA fluorescence assay
|
None
|
7.0
nM
|
|
Binding affinity to Escherichia coli ribosome assessed as inhibition of transcription-translational activity by luciferase assay
|
Escherichia coli
|
32.0
nM
|
|
Inhibition of rat phospholipase C
|
Rattus norvegicus
|
7.9
nM
|
|
Inhibition of HIV1 TAR RNA
|
Human immunodeficiency virus 1
|
417.0
nM
|
|
Binding affinity to human pre-hsa-mir-155 miRNA assessed as inhibition of dicer-catalysed (33P)-labelled pre-miRNA processing at 1 mM after 1 hr by PAGE analysis
|
Homo sapiens
|
10.0
%
|
|
Binding affinity to human pre-hsa-mir-155 miRNA assessed as inhibition of dicer-catalysed (33P)-labelled pre-miRNA processing at 1 mM after 1 hr by PAGE analysis
|
Homo sapiens
|
10.0
%
|
|
Inhibition of TRPV1-mediated membrane currents in human DRG neurons
|
Homo sapiens
|
400.0
nM
|
|
Inhibition of pre-miR-372 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis at 200 uM by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer
|
Not specified
|
60.0
%
|
|
Inhibition of pre-miR-373 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis at 200 uM by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer
|
Not specified
|
60.0
%
|
|
Inhibition of pre-miR-17 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis at 200 uM by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer
|
Not specified
|
60.0
%
|
|
Inhibition of pre-miR-21 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis at 200 uM by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer
|
Not specified
|
60.0
%
|
|
Inhibition of ethidium bromide binding to r(CGCAAAUUUGCG)2 RNA (unknown origin) at 1:1 ratio of ligand:RNA measured after 5 mins by fluorescent intercalator displacement assay relative to control
|
Not specified
|
20.4
%
|
|
Displacement of F-NEO from Escherichia coli rRNA-A site after 10 to 20 mins by fluorescence assay
|
Escherichia coli
|
87.0
nM
|
|
Displacement of F-NEO from human cytosolic rRNA-A site after 10 to 20 mins by fluorescence assay
|
Homo sapiens
|
76.0
nM
|
|
Binding affinity to rRNA-A site in human MDA-MB-231 cells assessed as inhibition of protein translation
|
Homo sapiens
|
139.0
nM
|
|
Binding affinity to biotinylated pre-miRNA-21 (unknown origin) by SPR analysis
|
Not specified
|
100.0
nM
|
|
Binding affinity to 5'-fluorescein-tagged Escherichia coli ribosomal A site wt-bac duplex RNA incubated for 2 mins by fluorescence spectrophotometric analysis
|
Escherichia coli
|
1.0
nM
|
|
Binding affinity to 5'-fluorescein-tagged human mitochondrial ribosome A site mutant duplex RNA incubated for 2 mins by fluorescence spectrophotometry analysis
|
Homo sapiens
|
100.0
nM
|
|
Binding affinity to 5'-fluorescein-tagged Escherichia coli ribosomal A site wt-bac duplex RNA assessed as conformational change in RNA by measuring decrease in fluorescence intensity incubated for 2 mins by fluorescence spectrophotometric analysis
|
Escherichia coli
|
20.0
%
|
|
Binding affinity to 5'-fluorescein-tagged bacterial ribosomal A site 27-nucleotide hairpin RNA construct by fluorescence analysis
|
Bacteria
|
5.0
nM
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
13.52
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.07
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.07
%
|
|
Ototoxicity against C57BL/6 mouse cochlea hair cells assessed as reduction in cell viability at 0.1 mM incubated for 23 hrs by FITC-phalloidin staining-based assay
|
Mus musculus
|
20.0
%
|
|