EcoDrugPlus


Synonyms	RPX-7009 RPX7009 Vaborbactam
Status
Molecule Category	Free-form
UNII	1C75676F8V

Synonyms

RPX-7009

RPX7009

Vaborbactam

Status

Molecule Category

Free-form

UNII

1C75676F8V


InChI Key	IOOWNWLVCOUUEX-WPRPVWTQSA-N
Smiles	O=C(O)C[C@@H]1CC[C@H](NC(=O)Cc2cccs2)B(O)O1
InChI	InChI=1S/C12H16BNO5S/c15-11(7-9-2-1-5-20-9)14-10-4-3-8(6-12(16)17)19-13(10)18/h1-2,5,8,10,18H,3-4,6-7H2,(H,14,15)(H,16,17)/t8-,10-/m0/s1

InChI Key

IOOWNWLVCOUUEX-WPRPVWTQSA-N

Smiles

O=C(O)C[C@@H]1CC[C@H](NC(=O)Cc2cccs2)B(O)O1

InChI

InChI=1S/C12H16BNO5S/c15-11(7-9-2-1-5-20-9)14-10-4-3-8(6-12(16)17)19-13(10)18/h1-2,5,8,10,18H,3-4,6-7H2,(H,14,15)(H,16,17)/t8-,10-/m0/s1

Property Name	Value
Molecular Formula	C12H16BNO5S
Molecular Weight	297.14

Property Name

Value

Molecular Formula

C12H16BNO5S

Molecular Weight

297.14

Mechanism of Action	Action	Reference
Carbepenem-hydrolyzing beta-lactamase KPC inhibitor	INHIBITOR	FDA

Mechanism of Action

Action

Reference

Carbepenem-hydrolyzing beta-lactamase KPC inhibitor

INHIBITOR

FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	56	-

Targets

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Enzyme Hydrolase

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bacteria	-	90-440	-	29-29	-
Escherichia coli	-	-	-	21-140	-
Klebsiella pneumoniae	-	35	-	-	-

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Bacteria

90-440

29-29

Escherichia coli

21-140

Klebsiella pneumoniae

Resources	Reference
ChEMBL	CHEMBL3317857
DrugBank	DB12107
DrugCentral	5253
FDA SRS	1C75676F8V
Guide to Pharmacology	10871
PDB	4D6
PubChem	56649692
SureChEMBL	SCHEMBL620289

Resources

Reference

ChEMBL

DrugBank

DrugCentral

FDA SRS

Guide to Pharmacology

PDB

PubChem

SureChEMBL

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

VABORBACTAM

Structure

Physicochemical Descriptors

Pharmacology

Cross References