PRALICIGUAT


Synonyms	IW-1973 Praliciguat
Status
Molecule Category	Free-form
UNII	R1S0H458SA

Structure


InChI Key	CYSJNTQNMDWAJV-UHFFFAOYSA-N
Smiles	OC(CNc1nc(-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)ncc1F)(C(F)(F)F)C(F)(F)F
InChI	InChI=1S/C21H14F8N6O2/c22-12-4-2-1-3-11(12)9-35-16(14-5-6-37-34-14)7-15(33-35)18-30-8-13(23)17(32-18)31-10-19(36,20(24,25)26)21(27,28)29/h1-8,36H,9-10H2,(H,30,31,32)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H14F8N6O2
Molecular Weight	534.37
AlogP	4.59
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	7.0
Polar Surface Area	101.89
Molecular species	NEUTRAL
Aromatic Rings	4.0
Heavy Atoms	37.0

Pharmacology

Mechanism of Action	Action	Reference
Soluble guanylate cyclase activator	ACTIVATOR	PubMed PubMed

Target Conservation


Protein: Soluble guanylate cyclase Description: Guanylate cyclase soluble subunit alpha-2 Organism : Homo sapiens P33402 ENSG00000152402












Protein: Soluble guanylate cyclase Description: Guanylate cyclase soluble subunit alpha-1 Organism : Homo sapiens Q02108 ENSG00000164116











Protein: Soluble guanylate cyclase Description: Guanylate cyclase soluble subunit beta-1 Organism : Homo sapiens Q02153 ENSG00000061918

Related Entries

Cross References

Resources	Reference
ChEBI	142431
ChEMBL	CHEMBL4297214
DrugBank	DB16300
FDA SRS	R1S0H458SA
Guide to Pharmacology	9900
PubChem	86269973
SureChEMBL	SCHEMBL16082414

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025