Synonyms | |
Status | |
Molecule Category | Free-form |
UNII | OJ8EG4264P |
EPA CompTox | DTXSID20229231 |
InChI Key | JFHJGXQFESYQGY-UHFFFAOYSA-N | |
---|---|---|
Smiles | ||
InChI |
|
Property Name | Value | |
---|---|---|
Molecular Formula | C22H24N6O2 | |
Molecular Weight | 404.47 | |
AlogP | 3.12 | |
Hydrogen Bond Acceptor | 6.0 | |
Hydrogen Bond Donor | 1.0 | |
Number of Rotational Bond | 4.0 | |
Polar Surface Area | 75.52 | |
Molecular species | BASE | |
Aromatic Rings | 3.0 | |
Heavy Atoms | 30.0 |
Mechanism of Action | Action | Reference | |
---|---|---|---|
Corticotropin releasing factor receptor 1 antagonist | ANTAGONIST | PubMed PubMed |
Protein: Corticotropin releasing factor receptor 1 Description: Corticotropin-releasing factor receptor 1 Organism : Homo sapiens P34998 ENSG00000120088 |
||||
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | ||
---|---|---|---|---|---|---|---|
Membrane receptor
Family B G protein-coupled receptor
Peptide receptor (family B GPCR)
Corticotropin releasing factor receptor
Corticotropin releasing factor receptor
|
- | 66 | 72 | - | - |
Resources | Reference | |
---|---|---|
ChEMBL | CHEMBL514270 | |
DrugBank | DB12910 | |
FDA SRS | OJ8EG4264P | |
PubChem | 11223423 | |
SureChEMBL | SCHEMBL2189548 | |
ZINC | ZINC000006716350 |