|
Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytes
|
None
|
260.0
nM
|
|
|
Inhibitory activity against 12-lipoxygenase in rat platelet rich plasma
|
None
|
15.0
nM
|
|
|
Inhibition of cell surface aminopeptidase N (APN/CD13) at 0.3*10e-3 M compound concentration
|
None
|
57.0
%
|
|
|
Ex vivo inhibition of LTB4 production was measured in dog blood
|
Canis lupus familiaris
|
100.0
mg kg-1
|
|
|
Inhibition of neutral endopeptidase (NEP/CD13) at 0.3*10e-3 M compound concentration
|
None
|
36.0
%
|
|
|
Inhibition of human E-selectin after 2 hrs at 100 uM
|
Homo sapiens
|
37.6
%
|
|
|
Inhibition of human P-selectin after 2 hrs at 100 uM
|
Homo sapiens
|
52.0
%
|
|
|
Inhibition of human L-selectin after 2 hrs at 100 uM
|
Homo sapiens
|
51.7
%
|
|
|
Inhibition of 12-hLO
|
None
|
860.0
nM
|
|
|
Inhibition of cow milk xanthine oxidase at 50 ug/mL
|
Bos taurus
|
85.5
%
|
|
|
Inhibition of Saccharomyces cerevisiae fatty acid synthase
|
Saccharomyces cerevisiae
|
25.0
ug.mL-1
|
|
|
Antifungal activity against Candida albicans ATCC 90028
|
Candida albicans
|
6.0
ug.mL-1
|
|
|
Antifungal activity against Cryptococcus neoformans ATCC 90113
|
Cryptococcus neoformans
|
50.0
ug.mL-1
|
|
|
Inhibition of human prolyl oligopeptidase at 50 uM in presence of 0.01% Triton X-100
|
Homo sapiens
|
51.0
%
|
|
|
Inhibition of human prolyl oligopeptidase at 50 uM after 20 mins microcentrifugation
|
Homo sapiens
|
64.0
%
|
|
|
Inhibition of human prolyl oligopeptidase at 50 uM preincubated for 5 mins
|
Homo sapiens
|
60.0
%
|
|
|
Inhibition of human prolyl oligopeptidase at 50 uM preincubated for 10 mins
|
Homo sapiens
|
81.0
%
|
|
|
Inhibition of human prolyl oligopeptidase at 50 uM preincubated for 15 mins
|
Homo sapiens
|
77.0
%
|
|
|
Inhibition of human prolyl oligopeptidase at 50 uM preincubated for 30 mins
|
Homo sapiens
|
84.0
%
|
|
|
Inhibition of trypsin by protease assay system
|
None
|
500.0
nM
|
|
|
Inhibition of polyhistidine tagged yeast prion protein Sup35 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid polymerization at 50 uM by thioflavin T fluorescence assay relative to untreated control
|
Saccharomyces cerevisiae
|
95.4
%
|
|
|
Inhibition of polyhistidine tagged yeast prion protein Sup35 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid polymerization at 50 uM in presence of 5 mg/ml BSA by thioflavin T fluorescence assay relative to untreated control
|
Saccharomyces cerevisiae
|
17.6
%
|
|
|
Inhibition of mouse prion protein (89-230) assessed as inhibition of amyloid polymerization at 50 uM by thioflavin T fluorescence assay relative to untreated control
|
Mus musculus
|
34.3
%
|
|
|
Inhibition of Beta-lactamase at 30 uM by nitrocefin hydrolysis assay
|
None
|
51.8
%
|
|
|
Inhibition of Beta-lactamase at 30 uM in presence of 0.01% Triton X-100 by nitrocefin hydrolysis assay
|
None
|
0.0
%
|
|
|
Inhibition of lipoxygenase at 1000 uM
|
None
|
22.5
%
|
|
|
Inhibition of TNFalpha in LPS-stimulated mouse RAW264.7 cells at 10 uM after 2 hrs treated after 14 hrs of LPS challenge by FACS analysis
|
Mus musculus
|
71.3
%
|
|
|
Inhibition of CYP1B1 EROD activity assessed as inhibition of deethylation of 7-ethoxyresorufin to resorufin
|
None
|
260.0
nM
|
|
|
Inhibition of human 15-lipoxygenase
|
Homo sapiens
|
600.0
nM
|
|
|
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 25 uM preincubated for 1 hr before LPS challenge measured after 24 hrs by Griess method
|
Mus musculus
|
11.13
%
|
|
|
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production at 25 uM by EIA
|
Mus musculus
|
60.87
%
|
|
|
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method
|
Electrophorus electricus
|
-3.74
%
|
|
|
Inhibition of horse BChE at 2 mg/ml by Ellman's method
|
Equus caballus
|
15.03
%
|
|
|
Inhibition of Avian myeloblastosis virus reverse transcriptase
|
Avian myeloblastosis virus
|
95.0
%
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
91.06
%
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
90.2
%
|
|
|
Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins
|
None
|
18.2
ug.mL-1
|
|
|
Inhibition of recombinant HIV-1 integrase strand transfer activity using 32P 5' end-labeled linear 21'mer as substrate preincubated for 30 mins prior to substrate challenge by phosphorimaging analysis
|
Human immunodeficiency virus 1
|
780.0
nM
|
|
|
Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis
|
Human immunodeficiency virus 1
|
1.67
ug.mL-1
|
|
|
Antiviral activity against dengue virus 2 infected in african green monkey Vero cells assessed as reduction in viral replication dosed after adsorption with 200 FFU of virus for 1 hour by foci forming unit reduction assay
|
Dengue virus 2
|
6.46
ug.mL-1
|
|
|
Inhibition of soybean LOX using linoleic acid as substrate at 0.5 mM preincubated for 10 mins followed by substrate addition measured after 6 mins by spectrophotometric analysis
|
Glycine max
|
93.7
%
|
|
|
Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophenylphosphate as substrate at 20 uM for 60 mins by fluorescence analysis
|
Homo sapiens
|
80.5
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
18.0
%
|
|
|
Inhibition of F1F0-ATP synthase in Escherichia coli after 60 mins relative to control
|
Escherichia coli
|
100.0
%
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
88.98
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
93.67
%
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
20.0
nM
|
|
|
MERS 3CL-Pro protease inhibition percentage at 10 µM by FRET kind of response from peptide substrate
|
Middle East respiratory syndrome
|
47.0
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
1.2
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.7
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
1.2
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.7
%
|
|
|
Inhibition of cytochrome c (unknown origin) assessed as reduction in cyt c-CL complex formation at 10 uM incubated for 15 mins in presence of cardiolipin by Trp-59 fluorescence assay relative to control
|
Homo sapiens
|
91.0
%
|
|
|
Inhibition of cytochrome c (unknown origin) assessed as reduction in cyt c-CL peroxidase activity at 10 uM up to 20 mins in presence of cardiolipin by Amplex red staining based fluorescence assay relative to control
|
Homo sapiens
|
71.0
%
|
|
|
Inhibition of cytochrome c (unknown origin) assessed as reduction reduction of cyt c from its ferric state to ferrous state at 10 uM incubated for 20 mins in presence of cardiolipin by UV-vis Spectrophotometric assay relative to control
|
Homo sapiens
|
79.0
%
|
|
|
Inhibition of P4 induced antiproliferative activity against CD-1 mouse uterine epithelial cell at 25 mg/kg, ip for 7 days by immunohistochemistry method
|
Mus musculus
|
32.0
%
|
|
