Synonyms | |
Status | |
Molecule Category | Free-form |
UNII | CER0OPG92L |
InChI Key | UOFYSRZSLXWIQB-UHFFFAOYSA-N | |
---|---|---|
Smiles | ||
InChI |
|
Property Name | Value | |
---|---|---|
Molecular Formula | C26H26FN7O2 | |
Molecular Weight | 487.54 | |
AlogP | 4.51 | |
Hydrogen Bond Acceptor | 7.0 | |
Hydrogen Bond Donor | 3.0 | |
Number of Rotational Bond | 7.0 | |
Polar Surface Area | 98.41 | |
Molecular species | NEUTRAL | |
Aromatic Rings | 4.0 | |
Heavy Atoms | 36.0 |
Mechanism of Action | Action | Reference | |
---|---|---|---|
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | Other PubMed ClinicalTrials PubMed PubMed Other Other |
Protein: Epidermal growth factor receptor erbB1 Description: Epidermal growth factor receptor Organism : Homo sapiens P00533 ENSG00000146648 |
||||
Protein: Tyrosine-protein kinase BTK Description: Tyrosine-protein kinase BTK Organism : Homo sapiens Q06187 ENSG00000010671 |
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Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | ||
---|---|---|---|---|---|---|---|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Tec family
|
- | - | - | - | 80 |
Resources | Reference | |
---|---|---|
ChEMBL | CHEMBL4297865 | |
DrugBank | DB15327 | |
FDA SRS | CER0OPG92L | |
Guide to Pharmacology | 10044 | |
PubChem | 72734520 | |
SureChEMBL | SCHEMBL15453394 | |
ZINC | ZINC000142081723 |