FIBOFLAPON

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Search structure


Synonyms	AM-803 Am803 Fiboflapon GSK-2190915 GSK2190915 GSK2190915B
Status
Molecule Category	Free-form
UNII	Y1NA96IX3T
EPA CompTox	DTXSID20239496

Structure


InChI Key	DFQGDHBGRSTTHX-UHFFFAOYSA-N
Smiles	CCOc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)cn1
InChI	InChI=1S/C38H43N3O4S/c1-8-44-34-18-14-28(22-40-34)27-12-10-26(11-13-27)23-41-32-17-16-30(45-24-29-15-9-25(2)21-39-29)19-31(32)35(46-37(3,4)5)33(41)20-38(6,7)36(42)43/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C38H43N3O4S
Molecular Weight	637.85
AlogP	8.98
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	12.0
Polar Surface Area	86.47
Molecular species	ACID
Aromatic Rings	5.0
Heavy Atoms	46.0

Pharmacology

Mechanism of Action	Action	Reference
5-lipoxygenase activating protein inhibitor	INHIBITOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Other cytosolic protein	-	0.7-506	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.7-506	-	-	-
Rattus norvegicus	-	16-239	-	-	-

Target Conservation


Protein: 5-lipoxygenase activating protein Description: Arachidonate 5-lipoxygenase-activating protein Organism : Homo sapiens P20292 ENSG00000132965

Cross References

Resources	Reference
ChEMBL	CHEMBL1922660
DrugBank	DB06346
FDA SRS	Y1NA96IX3T
PubChem	44473151
SureChEMBL	SCHEMBL11820
ZINC	ZINC000068247071

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025