INFIGRATINIB


Synonyms	BGJ-398 BGJ398 Bgj-398 Infigratinib MVP-BGJ398 NVP-BGJ398
Status
Molecule Category	Free-form
UNII	A4055ME1VK
EPA CompTox	DTXSID70236238

Structure


InChI Key	QADPYRIHXKWUSV-UHFFFAOYSA-N
Smiles	CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1
InChI	InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C26H31Cl2N7O3
Molecular Weight	560.49
AlogP	5.35
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	8.0
Polar Surface Area	95.09
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	38.0

Pharmacology

Mechanism of Action	Action	Reference
Fibroblast growth factor receptor inhibitor	INHIBITOR	PubMed Other

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	0.59-581	-	-	-
Membrane receptor Frizzled family G protein-coupled receptor Smoothened receptor (frizzled family GPCR)	-	-	-	46.5	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.59-172	-	46.5	10-83.67
Mus musculus	-	132.6-581	-	-	-
Rattus norvegicus	-	-	-	-	59.5-98.2

Target Conservation


Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 1 Organism : Homo sapiens P11362 ENSG00000077782












Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 2 Organism : Homo sapiens P21802 ENSG00000066468












Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 4 Organism : Homo sapiens P22455 ENSG00000160867










Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 3 Organism : Homo sapiens P22607 ENSG00000068078

Related Entries

Cross References

Resources	Reference
ChEBI	63451
ChEMBL	CHEMBL1852688
DrugBank	DB11886
FDA SRS	A4055ME1VK
Guide to Pharmacology	7877
PDB	07J
PubChem	53235510
SureChEMBL	SCHEMBL374435
ZINC	ZINC000072105034

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025