|
Inhibition of mTOR
|
None
|
0.8
nM
|
|
|
Inhibition of mTORC2 in human MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser473 after 2 hrs
|
Homo sapiens
|
24.0
nM
|
|
|
Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction of pS6 phosphorylation at Ser235/236 after 2 hrs
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cells
|
Homo sapiens
|
0.13
nM
|
|
|
SANGER: Inhibition of human NCI-H1563 cell growth in a cell viability assay.
|
Homo sapiens
|
789.26
nM
|
|
|
SANGER: Inhibition of human NCI-H1573 cell growth in a cell viability assay.
|
Homo sapiens
|
902.29
nM
|
|
|
SANGER: Inhibition of human NCI-H1581 cell growth in a cell viability assay.
|
Homo sapiens
|
189.66
nM
|
|
|
SANGER: Inhibition of human NCI-H1623 cell growth in a cell viability assay.
|
Homo sapiens
|
762.61
nM
|
|
|
SANGER: Inhibition of human NCI-H1648 cell growth in a cell viability assay.
|
Homo sapiens
|
701.73
nM
|
|
|
SANGER: Inhibition of human NCI-H1770 cell growth in a cell viability assay.
|
Homo sapiens
|
802.1
nM
|
|
|
SANGER: Inhibition of human NCI-H1792 cell growth in a cell viability assay.
|
Homo sapiens
|
971.01
nM
|
|
|
SANGER: Inhibition of human NCI-H1793 cell growth in a cell viability assay.
|
Homo sapiens
|
534.47
nM
|
|
|
SANGER: Inhibition of human NCI-H209 cell growth in a cell viability assay.
|
Homo sapiens
|
54.53
nM
|
|
|
SANGER: Inhibition of human NCI-H2347 cell growth in a cell viability assay.
|
Homo sapiens
|
824.01
nM
|
|
|
SANGER: Inhibition of human NCI-H2452 cell growth in a cell viability assay.
|
Homo sapiens
|
619.17
nM
|
|
|
SANGER: Inhibition of human NCI-H28 cell growth in a cell viability assay.
|
Homo sapiens
|
586.75
nM
|
|
|
SANGER: Inhibition of human NCI-H292 cell growth in a cell viability assay.
|
Homo sapiens
|
291.64
nM
|
|
|
SANGER: Inhibition of human NCI-H460 cell growth in a cell viability assay.
|
Homo sapiens
|
505.97
nM
|
|
|
SANGER: Inhibition of human NCI-H520 cell growth in a cell viability assay.
|
Homo sapiens
|
348.34
nM
|
|
|
SANGER: Inhibition of human NCI-H522 cell growth in a cell viability assay.
|
Homo sapiens
|
629.92
nM
|
|
|
SANGER: Inhibition of human NCI-H650 cell growth in a cell viability assay.
|
Homo sapiens
|
791.44
nM
|
|
|
SANGER: Inhibition of human NCI-H720 cell growth in a cell viability assay.
|
Homo sapiens
|
29.38
nM
|
|
|
SANGER: Inhibition of human NCI-H747 cell growth in a cell viability assay.
|
Homo sapiens
|
759.91
nM
|
|
|
SANGER: Inhibition of human NCI-SNU-1 cell growth in a cell viability assay.
|
Homo sapiens
|
323.31
nM
|
|
|
SANGER: Inhibition of human NEC8 cell growth in a cell viability assay.
|
Homo sapiens
|
416.95
nM
|
|
|
SANGER: Inhibition of human NKM-1 cell growth in a cell viability assay.
|
Homo sapiens
|
200.29
nM
|
|
|
SANGER: Inhibition of human NOS-1 cell growth in a cell viability assay.
|
Homo sapiens
|
410.74
nM
|
|
|
SANGER: Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay.
|
Homo sapiens
|
700.63
nM
|
|
|
SANGER: Inhibition of human NUGC-3 cell growth in a cell viability assay.
|
Homo sapiens
|
706.91
nM
|
|
|
SANGER: Inhibition of human OAW-42 cell growth in a cell viability assay.
|
Homo sapiens
|
591.62
nM
|
|
|
SANGER: Inhibition of human OCUB-M cell growth in a cell viability assay.
|
Homo sapiens
|
826.75
nM
|
|
|
SANGER: Inhibition of human OE33 cell growth in a cell viability assay.
|
Homo sapiens
|
799.14
nM
|
|
|
SANGER: Inhibition of human OMC-1 cell growth in a cell viability assay.
|
Homo sapiens
|
727.38
nM
|
|
|
SANGER: Inhibition of human OVCAR-4 cell growth in a cell viability assay.
|
Homo sapiens
|
819.11
nM
|
|
|
SANGER: Inhibition of human OVCAR-5 cell growth in a cell viability assay.
|
Homo sapiens
|
429.33
nM
|
|
|
SANGER: Inhibition of human P30-OHK cell growth in a cell viability assay.
|
Homo sapiens
|
327.05
nM
|
|
|
SANGER: Inhibition of human PA-1 cell growth in a cell viability assay.
|
Homo sapiens
|
336.19
nM
|
|
|
SANGER: Inhibition of human PANC-08-13 cell growth in a cell viability assay.
|
Homo sapiens
|
573.89
nM
|
|
|
SANGER: Inhibition of human PC-14 cell growth in a cell viability assay.
|
Homo sapiens
|
589.7
nM
|
|
|
SANGER: Inhibition of human PC-3 cell growth in a cell viability assay.
|
Homo sapiens
|
722.3
nM
|
|
|
SANGER: Inhibition of human PFSK-1 cell growth in a cell viability assay.
|
Homo sapiens
|
830.39
nM
|
|
|
SANGER: Inhibition of human PSN1 cell growth in a cell viability assay.
|
Homo sapiens
|
770.57
nM
|
|
|
SANGER: Inhibition of human QIMR-WIL cell growth in a cell viability assay.
|
Homo sapiens
|
451.5
nM
|
|
|
SANGER: Inhibition of human RKO cell growth in a cell viability assay.
|
Homo sapiens
|
868.17
nM
|
|
|
SANGER: Inhibition of human RPMI-7951 cell growth in a cell viability assay.
|
Homo sapiens
|
735.33
nM
|
|
|
SANGER: Inhibition of human RPMI-8226 cell growth in a cell viability assay.
|
Homo sapiens
|
285.89
nM
|
|
|
SANGER: Inhibition of human RPMI-8866 cell growth in a cell viability assay.
|
Homo sapiens
|
858.22
nM
|
|
|
SANGER: Inhibition of human RS4-11 cell growth in a cell viability assay.
|
Homo sapiens
|
759.43
nM
|
|
|
SANGER: Inhibition of human RT-112 cell growth in a cell viability assay.
|
Homo sapiens
|
849.37
nM
|
|
|
SANGER: Inhibition of human RVH-421 cell growth in a cell viability assay.
|
Homo sapiens
|
636.39
nM
|
|
|
SANGER: Inhibition of human RXF393 cell growth in a cell viability assay.
|
Homo sapiens
|
928.97
nM
|
|
|
SANGER: Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay.
|
Homo sapiens
|
169.83
nM
|
|
|
SANGER: Inhibition of human SBC-1 cell growth in a cell viability assay.
|
Homo sapiens
|
45.81
nM
|
|
|
SANGER: Inhibition of human SCC-4 cell growth in a cell viability assay.
|
Homo sapiens
|
585.41
nM
|
|
|
SANGER: Inhibition of human SF126 cell growth in a cell viability assay.
|
Homo sapiens
|
887.14
nM
|
|
|
SANGER: Inhibition of human SF295 cell growth in a cell viability assay.
|
Homo sapiens
|
685.07
nM
|
|
|
SANGER: Inhibition of human SJSA-1 cell growth in a cell viability assay.
|
Homo sapiens
|
445.54
nM
|
|
|
SANGER: Inhibition of human SK-LU-1 cell growth in a cell viability assay.
|
Homo sapiens
|
392.08
nM
|
|
|
SANGER: Inhibition of human SK-MEL-2 cell growth in a cell viability assay.
|
Homo sapiens
|
641.53
nM
|
|
|
SANGER: Inhibition of human SK-MEL-28 cell growth in a cell viability assay.
|
Homo sapiens
|
559.1
nM
|
|
|
SANGER: Inhibition of human SK-MES-1 cell growth in a cell viability assay.
|
Homo sapiens
|
438.48
nM
|
|
|
SANGER: Inhibition of human SK-NEP-1 cell growth in a cell viability assay.
|
Homo sapiens
|
625.02
nM
|
|
|
SANGER: Inhibition of human SK-OV-3 cell growth in a cell viability assay.
|
Homo sapiens
|
671.87
nM
|
|
|
SANGER: Inhibition of human SN12C cell growth in a cell viability assay.
|
Homo sapiens
|
806.68
nM
|
|
|
SANGER: Inhibition of human SNU-423 cell growth in a cell viability assay.
|
Homo sapiens
|
814.22
nM
|
|
|
SANGER: Inhibition of human SNU-449 cell growth in a cell viability assay.
|
Homo sapiens
|
959.24
nM
|
|
|
SANGER: Inhibition of human SW13 cell growth in a cell viability assay.
|
Homo sapiens
|
983.92
nM
|
|
|
SANGER: Inhibition of human SW1710 cell growth in a cell viability assay.
|
Homo sapiens
|
631.67
nM
|
|
|
SANGER: Inhibition of human SW780 cell growth in a cell viability assay.
|
Homo sapiens
|
575.95
nM
|
|
|
SANGER: Inhibition of human SW962 cell growth in a cell viability assay.
|
Homo sapiens
|
471.9
nM
|
|
|
SANGER: Inhibition of human SW982 cell growth in a cell viability assay.
|
Homo sapiens
|
685.01
nM
|
|
|
SANGER: Inhibition of human T47D cell growth in a cell viability assay.
|
Homo sapiens
|
274.75
nM
|
|
|
SANGER: Inhibition of human 22RV1 cell growth in a cell viability assay.
|
Homo sapiens
|
707.17
nM
|
|
|
SANGER: Inhibition of human 697 cell growth in a cell viability assay.
|
Homo sapiens
|
273.67
nM
|
|
|
SANGER: Inhibition of human 8305C cell growth in a cell viability assay.
|
Homo sapiens
|
707.55
nM
|
|
|
SANGER: Inhibition of human A101D cell growth in a cell viability assay.
|
Homo sapiens
|
489.68
nM
|
|
|
SANGER: Inhibition of human A204 cell growth in a cell viability assay.
|
Homo sapiens
|
189.7
nM
|
|
|
SANGER: Inhibition of human A2058 cell growth in a cell viability assay.
|
Homo sapiens
|
973.6
nM
|
|
|
SANGER: Inhibition of human A3-KAW cell growth in a cell viability assay.
|
Homo sapiens
|
297.4
nM
|
|
|
SANGER: Inhibition of human A375 cell growth in a cell viability assay.
|
Homo sapiens
|
751.93
nM
|
|
|
SANGER: Inhibition of human A427 cell growth in a cell viability assay.
|
Homo sapiens
|
961.98
nM
|
|
|
SANGER: Inhibition of human A431 cell growth in a cell viability assay.
|
Homo sapiens
|
831.16
nM
|
|
|
SANGER: Inhibition of human A549 cell growth in a cell viability assay.
|
Homo sapiens
|
195.5
nM
|
|
|
SANGER: Inhibition of human A704 cell growth in a cell viability assay.
|
Homo sapiens
|
817.98
nM
|
|
|
SANGER: Inhibition of human ACN cell growth in a cell viability assay.
|
Homo sapiens
|
942.77
nM
|
|
|
SANGER: Inhibition of human AN3-CA cell growth in a cell viability assay.
|
Homo sapiens
|
79.51
nM
|
|
|
SANGER: Inhibition of human ATN-1 cell growth in a cell viability assay.
|
Homo sapiens
|
705.9
nM
|
|
|
SANGER: Inhibition of human AsPC-1 cell growth in a cell viability assay.
|
Homo sapiens
|
737.95
nM
|
|
|
SANGER: Inhibition of human BB65-RCC cell growth in a cell viability assay.
|
Homo sapiens
|
308.05
nM
|
|
|
SANGER: Inhibition of human BCPAP cell growth in a cell viability assay.
|
Homo sapiens
|
587.91
nM
|
|
|
SANGER: Inhibition of human BEN cell growth in a cell viability assay.
|
Homo sapiens
|
212.93
nM
|
|
|
SANGER: Inhibition of human BFTC-905 cell growth in a cell viability assay.
|
Homo sapiens
|
621.26
nM
|
|
|
SANGER: Inhibition of human BHT-101 cell growth in a cell viability assay.
|
Homo sapiens
|
407.87
nM
|
|
|
SANGER: Inhibition of human BHY cell growth in a cell viability assay.
|
Homo sapiens
|
887.34
nM
|
|
|
SANGER: Inhibition of human BPH-1 cell growth in a cell viability assay.
|
Homo sapiens
|
883.95
nM
|
|
|
SANGER: Inhibition of human BV-173 cell growth in a cell viability assay.
|
Homo sapiens
|
90.61
nM
|
|
|
SANGER: Inhibition of human BxPC-3 cell growth in a cell viability assay.
|
Homo sapiens
|
888.33
nM
|
|
|
SANGER: Inhibition of human C-33-A cell growth in a cell viability assay.
|
Homo sapiens
|
904.42
nM
|
|
|
SANGER: Inhibition of human C32 cell growth in a cell viability assay.
|
Homo sapiens
|
724.84
nM
|
|
|
SANGER: Inhibition of human CAKI-1 cell growth in a cell viability assay.
|
Homo sapiens
|
746.29
nM
|
|
|
SANGER: Inhibition of human CAL-120 cell growth in a cell viability assay.
|
Homo sapiens
|
860.41
nM
|
|
|
SANGER: Inhibition of human CAL-12T cell growth in a cell viability assay.
|
Homo sapiens
|
780.29
nM
|
|
|
SANGER: Inhibition of human CAL-33 cell growth in a cell viability assay.
|
Homo sapiens
|
864.95
nM
|
|
|
SANGER: Inhibition of human CAL-39 cell growth in a cell viability assay.
|
Homo sapiens
|
522.68
nM
|
|
|
SANGER: Inhibition of human CAL-51 cell growth in a cell viability assay.
|
Homo sapiens
|
196.51
nM
|
|
|
SANGER: Inhibition of human CAL-62 cell growth in a cell viability assay.
|
Homo sapiens
|
799.24
nM
|
|
|
SANGER: Inhibition of human TE-5 cell growth in a cell viability assay.
|
Homo sapiens
|
684.05
nM
|
|
|
SANGER: Inhibition of human TI-73 cell growth in a cell viability assay.
|
Homo sapiens
|
456.86
nM
|
|
|
SANGER: Inhibition of human TYK-nu cell growth in a cell viability assay.
|
Homo sapiens
|
318.64
nM
|
|
|
SANGER: Inhibition of human U-2-OS cell growth in a cell viability assay.
|
Homo sapiens
|
759.7
nM
|
|
|
SANGER: Inhibition of human UACC-893 cell growth in a cell viability assay.
|
Homo sapiens
|
928.55
nM
|
|
|
SANGER: Inhibition of human VA-ES-BJ cell growth in a cell viability assay.
|
Homo sapiens
|
342.68
nM
|
|
|
SANGER: Inhibition of human VM-CUB-1 cell growth in a cell viability assay.
|
Homo sapiens
|
472.86
nM
|
|
|
SANGER: Inhibition of human VMRC-RCZ cell growth in a cell viability assay.
|
Homo sapiens
|
784.82
nM
|
|
|
SANGER: Inhibition of human WM-115 cell growth in a cell viability assay.
|
Homo sapiens
|
689.24
nM
|
|
|
SANGER: Inhibition of human YH-13 cell growth in a cell viability assay.
|
Homo sapiens
|
549.38
nM
|
|
|
SANGER: Inhibition of human CAMA-1 cell growth in a cell viability assay.
|
Homo sapiens
|
621.52
nM
|
|
|
SANGER: Inhibition of human CHL-1 cell growth in a cell viability assay.
|
Homo sapiens
|
327.03
nM
|
|
|
SANGER: Inhibition of human CHP-212 cell growth in a cell viability assay.
|
Homo sapiens
|
436.97
nM
|
|
|
SANGER: Inhibition of human COLO-684 cell growth in a cell viability assay.
|
Homo sapiens
|
457.26
nM
|
|
|
SANGER: Inhibition of human COLO-800 cell growth in a cell viability assay.
|
Homo sapiens
|
698.13
nM
|
|
|
SANGER: Inhibition of human COR-L88 cell growth in a cell viability assay.
|
Homo sapiens
|
422.67
nM
|
|
|
SANGER: Inhibition of human CP50-MEL-B cell growth in a cell viability assay.
|
Homo sapiens
|
883.84
nM
|
|
|
SANGER: Inhibition of human CTB-1 cell growth in a cell viability assay.
|
Homo sapiens
|
272.15
nM
|
|
|
SANGER: Inhibition of human CTV-1 cell growth in a cell viability assay.
|
Homo sapiens
|
86.41
nM
|
|
|
SANGER: Inhibition of human Ca9-22 cell growth in a cell viability assay.
|
Homo sapiens
|
787.36
nM
|
|
|
SANGER: Inhibition of human D-283MED cell growth in a cell viability assay.
|
Homo sapiens
|
147.23
nM
|
|
|
SANGER: Inhibition of human DB cell growth in a cell viability assay.
|
Homo sapiens
|
500.21
nM
|
|
|
SANGER: Inhibition of human DEL cell growth in a cell viability assay.
|
Homo sapiens
|
967.73
nM
|
|
|
SANGER: Inhibition of human DMS-114 cell growth in a cell viability assay.
|
Homo sapiens
|
936.77
nM
|
|
|
SANGER: Inhibition of human DMS-273 cell growth in a cell viability assay.
|
Homo sapiens
|
769.22
nM
|
|
|
SANGER: Inhibition of human DOHH-2 cell growth in a cell viability assay.
|
Homo sapiens
|
793.3
nM
|
|
|
SANGER: Inhibition of human DOK cell growth in a cell viability assay.
|
Homo sapiens
|
513.33
nM
|
|
|
SANGER: Inhibition of human DU-4475 cell growth in a cell viability assay.
|
Homo sapiens
|
80.47
nM
|
|
|
SANGER: Inhibition of human ECC10 cell growth in a cell viability assay.
|
Homo sapiens
|
350.35
nM
|
|
|
SANGER: Inhibition of human EFM-19 cell growth in a cell viability assay.
|
Homo sapiens
|
708.47
nM
|
|
|
SANGER: Inhibition of human EFO-27 cell growth in a cell viability assay.
|
Homo sapiens
|
679.79
nM
|
|
|
SANGER: Inhibition of human EGI-1 cell growth in a cell viability assay.
|
Homo sapiens
|
135.31
nM
|
|
|
SANGER: Inhibition of human EM-2 cell growth in a cell viability assay.
|
Homo sapiens
|
341.88
nM
|
|
|
SANGER: Inhibition of human EPLC-272H cell growth in a cell viability assay.
|
Homo sapiens
|
430.77
nM
|
|
|
SANGER: Inhibition of human ES1 cell growth in a cell viability assay.
|
Homo sapiens
|
555.18
nM
|
|
|
SANGER: Inhibition of human ES4 cell growth in a cell viability assay.
|
Homo sapiens
|
453.36
nM
|
|
|
SANGER: Inhibition of human ES5 cell growth in a cell viability assay.
|
Homo sapiens
|
93.5
nM
|
|
|
SANGER: Inhibition of human ES7 cell growth in a cell viability assay.
|
Homo sapiens
|
273.83
nM
|
|
|
SANGER: Inhibition of human ES8 cell growth in a cell viability assay.
|
Homo sapiens
|
365.53
nM
|
|
|
SANGER: Inhibition of human ETK-1 cell growth in a cell viability assay.
|
Homo sapiens
|
893.72
nM
|
|
|
SANGER: Inhibition of human EW-18 cell growth in a cell viability assay.
|
Homo sapiens
|
140.73
nM
|
|
|
SANGER: Inhibition of human EW-22 cell growth in a cell viability assay.
|
Homo sapiens
|
684.44
nM
|
|
|
SANGER: Inhibition of human EW-3 cell growth in a cell viability assay.
|
Homo sapiens
|
40.56
nM
|
|
|
SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay.
|
Homo sapiens
|
65.69
nM
|
|
|
SANGER: Inhibition of human G-401 cell growth in a cell viability assay.
|
Homo sapiens
|
309.86
nM
|
|
|
SANGER: Inhibition of human G-402 cell growth in a cell viability assay.
|
Homo sapiens
|
99.8
nM
|
|
|
SANGER: Inhibition of human GAMG cell growth in a cell viability assay.
|
Homo sapiens
|
556.58
nM
|
|
|
SANGER: Inhibition of human GCIY cell growth in a cell viability assay.
|
Homo sapiens
|
457.54
nM
|
|
|
SANGER: Inhibition of human GR-ST cell growth in a cell viability assay.
|
Homo sapiens
|
530.15
nM
|
|
|
SANGER: Inhibition of human H4 cell growth in a cell viability assay.
|
Homo sapiens
|
600.94
nM
|
|
|
SANGER: Inhibition of human H9 cell growth in a cell viability assay.
|
Homo sapiens
|
66.92
nM
|
|
|
SANGER: Inhibition of human HAL-01 cell growth in a cell viability assay.
|
Homo sapiens
|
202.97
nM
|
|
|
SANGER: Inhibition of human HCC1419 cell growth in a cell viability assay.
|
Homo sapiens
|
869.28
nM
|
|
|
SANGER: Inhibition of human HCC1569 cell growth in a cell viability assay.
|
Homo sapiens
|
852.07
nM
|
|
|
SANGER: Inhibition of human HCC1806 cell growth in a cell viability assay.
|
Homo sapiens
|
932.56
nM
|
|
|
SANGER: Inhibition of human HCC2218 cell growth in a cell viability assay.
|
Homo sapiens
|
206.88
nM
|
|
|
SANGER: Inhibition of human HD-MY-Z cell growth in a cell viability assay.
|
Homo sapiens
|
840.92
nM
|
|
|
SANGER: Inhibition of human HGC-27 cell growth in a cell viability assay.
|
Homo sapiens
|
264.14
nM
|
|
|
SANGER: Inhibition of human HH cell growth in a cell viability assay.
|
Homo sapiens
|
80.09
nM
|
|
|
SANGER: Inhibition of human HL-60 cell growth in a cell viability assay.
|
Homo sapiens
|
603.51
nM
|
|
|
SANGER: Inhibition of human HLE cell growth in a cell viability assay.
|
Homo sapiens
|
748.44
nM
|
|
|
SANGER: Inhibition of human HO-1-N-1 cell growth in a cell viability assay.
|
Homo sapiens
|
680.64
nM
|
|
|
SANGER: Inhibition of human HOS cell growth in a cell viability assay.
|
Homo sapiens
|
571.92
nM
|
|
|
SANGER: Inhibition of human HPAF-II cell growth in a cell viability assay.
|
Homo sapiens
|
807.94
nM
|
|
|
SANGER: Inhibition of human HSC-3 cell growth in a cell viability assay.
|
Homo sapiens
|
429.08
nM
|
|
|
SANGER: Inhibition of human HT cell growth in a cell viability assay.
|
Homo sapiens
|
293.8
nM
|
|
|
SANGER: Inhibition of human HT-1080 cell growth in a cell viability assay.
|
Homo sapiens
|
525.43
nM
|
|
|
SANGER: Inhibition of human HTC-C3 cell growth in a cell viability assay.
|
Homo sapiens
|
731.72
nM
|
|
|
SANGER: Inhibition of human Hs-578-T cell growth in a cell viability assay.
|
Homo sapiens
|
598.51
nM
|
|
|
SANGER: Inhibition of human HuH-7 cell growth in a cell viability assay.
|
Homo sapiens
|
433.72
nM
|
|
|
SANGER: Inhibition of human HuO-3N1 cell growth in a cell viability assay.
|
Homo sapiens
|
383.79
nM
|
|
|
SANGER: Inhibition of human HuO9 cell growth in a cell viability assay.
|
Homo sapiens
|
406.67
nM
|
|
|
SANGER: Inhibition of human IA-LM cell growth in a cell viability assay.
|
Homo sapiens
|
596.09
nM
|
|
|
SANGER: Inhibition of human IGROV-1 cell growth in a cell viability assay.
|
Homo sapiens
|
674.5
nM
|
|
|
SANGER: Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay.
|
Homo sapiens
|
531.95
nM
|
|
|
SANGER: Inhibition of human JVM-3 cell growth in a cell viability assay.
|
Homo sapiens
|
462.92
nM
|
|
|
SANGER: Inhibition of human KARPAS-45 cell growth in a cell viability assay.
|
Homo sapiens
|
33.71
nM
|
|
|
SANGER: Inhibition of human KE-37 cell growth in a cell viability assay.
|
Homo sapiens
|
432.47
nM
|
|
|
SANGER: Inhibition of human KG-1 cell growth in a cell viability assay.
|
Homo sapiens
|
568.84
nM
|
|
|
SANGER: Inhibition of human KGN cell growth in a cell viability assay.
|
Homo sapiens
|
610.49
nM
|
|
|
SANGER: Inhibition of human KNS-62 cell growth in a cell viability assay.
|
Homo sapiens
|
505.68
nM
|
|
|
SANGER: Inhibition of human KP-N-YS cell growth in a cell viability assay.
|
Homo sapiens
|
430.7
nM
|
|
|
SANGER: Inhibition of human KU-19-19 cell growth in a cell viability assay.
|
Homo sapiens
|
851.21
nM
|
|
|
SANGER: Inhibition of human KU812 cell growth in a cell viability assay.
|
Homo sapiens
|
80.43
nM
|
|
|
SANGER: Inhibition of human KYSE-140 cell growth in a cell viability assay.
|
Homo sapiens
|
781.68
nM
|
|
|
SANGER: Inhibition of human KYSE-150 cell growth in a cell viability assay.
|
Homo sapiens
|
661.86
nM
|
|
|
SANGER: Inhibition of human KYSE-450 cell growth in a cell viability assay.
|
Homo sapiens
|
827.25
nM
|
|
|
SANGER: Inhibition of human L-363 cell growth in a cell viability assay.
|
Homo sapiens
|
390.26
nM
|
|
|
SANGER: Inhibition of human LAMA-84 cell growth in a cell viability assay.
|
Homo sapiens
|
180.32
nM
|
|
|
SANGER: Inhibition of human LB1047-RCC cell growth in a cell viability assay.
|
Homo sapiens
|
340.47
nM
|
|
|
SANGER: Inhibition of human LB2241-RCC cell growth in a cell viability assay.
|
Homo sapiens
|
301.98
nM
|
|
|
SANGER: Inhibition of human LC-2-ad cell growth in a cell viability assay.
|
Homo sapiens
|
220.84
nM
|
|
|
SANGER: Inhibition of human LK-2 cell growth in a cell viability assay.
|
Homo sapiens
|
268.24
nM
|
|
|
SANGER: Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay.
|
Homo sapiens
|
353.14
nM
|
|
|
SANGER: Inhibition of human LOXIMVI cell growth in a cell viability assay.
|
Homo sapiens
|
551.23
nM
|
|
|
SANGER: Inhibition of human LU-139 cell growth in a cell viability assay.
|
Homo sapiens
|
23.31
nM
|
|
|
SANGER: Inhibition of human LU-99A cell growth in a cell viability assay.
|
Homo sapiens
|
776.49
nM
|
|
|
SANGER: Inhibition of human LXF-289 cell growth in a cell viability assay.
|
Homo sapiens
|
250.41
nM
|
|
|
SANGER: Inhibition of human LoVo cell growth in a cell viability assay.
|
Homo sapiens
|
202.02
nM
|
|
|
SANGER: Inhibition of human M14 cell growth in a cell viability assay.
|
Homo sapiens
|
471.7
nM
|
|
|
SANGER: Inhibition of human MC-IXC cell growth in a cell viability assay.
|
Homo sapiens
|
727.18
nM
|
|
|
SANGER: Inhibition of human MCF7 cell growth in a cell viability assay.
|
Homo sapiens
|
405.3
nM
|
|
|
SANGER: Inhibition of human MDA-MB-157 cell growth in a cell viability assay.
|
Homo sapiens
|
678.1
nM
|
|
|
SANGER: Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay.
|
Homo sapiens
|
577.41
nM
|
|
|
SANGER: Inhibition of human MDA-MB-361 cell growth in a cell viability assay.
|
Homo sapiens
|
508.7
nM
|
|
|
SANGER: Inhibition of human ME-180 cell growth in a cell viability assay.
|
Homo sapiens
|
146.81
nM
|
|
|
SANGER: Inhibition of human MEL-HO cell growth in a cell viability assay.
|
Homo sapiens
|
677.52
nM
|
|
|
SANGER: Inhibition of human MFE-280 cell growth in a cell viability assay.
|
Homo sapiens
|
430.32
nM
|
|
|
SANGER: Inhibition of human MFM-223 cell growth in a cell viability assay.
|
Homo sapiens
|
426.17
nM
|
|
|
SANGER: Inhibition of human MG-63 cell growth in a cell viability assay.
|
Homo sapiens
|
274.07
nM
|
|
|
SANGER: Inhibition of human MHH-ES-1 cell growth in a cell viability assay.
|
Homo sapiens
|
834.57
nM
|
|
|
SANGER: Inhibition of human MHH-PREB-1 cell growth in a cell viability assay.
|
Homo sapiens
|
747.36
nM
|
|
|
SANGER: Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay.
|
Homo sapiens
|
929.22
nM
|
|
|
SANGER: Inhibition of human ML-2 cell growth in a cell viability assay.
|
Homo sapiens
|
584.78
nM
|
|
|
SANGER: Inhibition of human MN-60 cell growth in a cell viability assay.
|
Homo sapiens
|
678.46
nM
|
|
|
SANGER: Inhibition of human MOLT-13 cell growth in a cell viability assay.
|
Homo sapiens
|
665.37
nM
|
|
|
SANGER: Inhibition of human MOLT-16 cell growth in a cell viability assay.
|
Homo sapiens
|
938.45
nM
|
|
|
SANGER: Inhibition of human MOLT-4 cell growth in a cell viability assay.
|
Homo sapiens
|
676.89
nM
|
|
|
SANGER: Inhibition of human MPP-89 cell growth in a cell viability assay.
|
Homo sapiens
|
469.47
nM
|
|
|
SANGER: Inhibition of human MSTO-211H cell growth in a cell viability assay.
|
Homo sapiens
|
577.51
nM
|
|
|
SANGER: Inhibition of human MV-4-11 cell growth in a cell viability assay.
|
Homo sapiens
|
103.47
nM
|
|
|
SANGER: Inhibition of human MZ2-MEL cell growth in a cell viability assay.
|
Homo sapiens
|
408.82
nM
|
|
|
SANGER: Inhibition of human NB14 cell growth in a cell viability assay.
|
Homo sapiens
|
164.47
nM
|
|
|
SANGER: Inhibition of human NB5 cell growth in a cell viability assay.
|
Homo sapiens
|
703.19
nM
|
|
|
SANGER: Inhibition of human NB69 cell growth in a cell viability assay.
|
Homo sapiens
|
135.0
nM
|
|
|
SANGER: Inhibition of human NBsusSR cell growth in a cell viability assay.
|
Homo sapiens
|
170.19
nM
|
|
|
SANGER: Inhibition of human NCI-H1048 cell growth in a cell viability assay.
|
Homo sapiens
|
586.45
nM
|
|
|
SANGER: Inhibition of human NCI-H1355 cell growth in a cell viability assay.
|
Homo sapiens
|
538.78
nM
|
|
|
SANGER: Inhibition of human NCI-H1437 cell growth in a cell viability assay.
|
Homo sapiens
|
606.19
nM
|
|
|
Inhibition of mTORC1-mediated S6 phosphorylation at Ser235/236 residue in human MDA-MB-468 cells after 2 hrs by Acumen laser scanning cytometry
|
Homo sapiens
|
26.92
nM
|
|
|
Inhibition of mTORC2-mediated AKT phosphorylation at Ser473 residue in human MDA-MB-468 cells after 2 hrs by Acumen laser scanning cytometry
|
Homo sapiens
|
23.99
nM
|
|
|
Cytotoxicity against human Glioma cells (HF2303) after 72 hrs by CelltiterGlo assay
|
Homo sapiens
|
0.7
nM
|
|
|
Cytotoxicity against human Glioma cells (HF2381) after 72 hrs by CelltiterGlo assay
|
Homo sapiens
|
0.7
nM
|
|
|
Cytotoxicity against human Glioma cells (HF2476) after 72 hrs by CelltiterGlo assay
|
Homo sapiens
|
0.7
nM
|
|
|
Cytotoxicity against human Glioma cells (HF2790) after 72 hrs by CelltiterGlo assay
|
Homo sapiens
|
0.7
nM
|
|
|
Cytotoxicity against human Glioma cells (HF2876) after 72 hrs by CelltiterGlo assay
|
Homo sapiens
|
0.7
nM
|
|
|
Cytotoxicity against human Glioma cells (HF2885) after 72 hrs by CelltiterGlo assay
|
Homo sapiens
|
0.7
nM
|
|
|
Cytotoxicity against human Glioma cells (HF3013) after 72 hrs by CelltiterGlo assay
|
Homo sapiens
|
0.7
nM
|
|
|
Alternative Enzyme Assay: The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibit phosphorylation by recombinant mTOR.Test compounds were prepared as 10 mM stock solutions in DMSO and diluted into water as required to give a range of final assay concentrations. Aliquots (2 ul) of each compound dilution were placed into a well of a Greiner 384-well low volume (LV) white polystyrene plate (Greiner Bio-one). A 10 ul mixture of recombinant purified mTOR enzyme, 1 uM biotinylated peptide substrate (Biotin-Ahx-Lys-Lys-Ala-Asn-Gln-Val-Phe-Leu-Gly-Phe-Thr-Tyr-Val-Ala-Pro-Ser-Val-Leu-Glu-Ser-Val-Lys-Glu-NH2; Bachem UK Ltd), ATP (20 uM) in a buffer solution [comprising Tris-HCl pH7.4 buffer (50 mM), EGTA (0.1 mM), bovine serum albumin (0.5 mg/ml), DTT (1.25 mM) and manganese chloride (10 mM)] were added to the assay plates and incubated with compound for 2 hours at room temperature.
|
Homo sapiens
|
8.9
nM
|
|
|
Antiproliferative activity against human A549 cells after 72 hrs by SRB assay
|
Homo sapiens
|
50.0
nM
|
|
|
Antiproliferative activity against human A375 cells after 72 hrs by SRB assay
|
Homo sapiens
|
120.0
nM
|
|
|
Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay
|
Homo sapiens
|
140.0
nM
|
|
|
Antiproliferative activity against human U87 cells after 72 hrs by SRB assay
|
Homo sapiens
|
190.0
nM
|
|
|
Antiproliferative activity against human NCI-H460 cells after 72 hrs by SRB assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human PI3K p110alpha/p85alpha at 10 uM using phosphatidylinositol 4,5-bisphosphate as substrate after 30 mins by HTRF assay relative to control
|
Homo sapiens
|
70.0
%
|
|
|
Inhibition of human PI3K p110beta/p85alpha at 10 uM using phosphatidylinositol 4,5-bisphosphate as substrate after 30 mins by HTRF assay relative to control
|
Homo sapiens
|
12.0
%
|
|
|
Inhibition of human PI3K p120gamma at 10 uM using phosphatidylinositol 4,5-bisphosphate as substrate after 30 mins by HTRF assay relative to control
|
Homo sapiens
|
29.0
%
|
|
|
Inhibition of human PI3K p110delta/p85alpha at 10 uM using phosphatidylinositol 4,5-bisphosphate as substrate after 30 mins by HTRF assay relative to control
|
Homo sapiens
|
59.0
%
|
|
|
Inhibition of human N-terminal FLAG-tagged mTOR (1362-end residues) in presence of [gamma33P]ATP after 40 mins
|
Homo sapiens
|
4.0
nM
|
|
|
Inhibition of mTOR (unknown origin) using ULight-4E-BP1 peptide substrate measured after 1 hr by Lance Ultra assay
|
Homo sapiens
|
8.0
nM
|
|
|
Antiproliferative activity against human U87MG cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
|
Homo sapiens
|
21.2
nM
|
|
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
|
Homo sapiens
|
27.0
nM
|
|
|
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
|
Homo sapiens
|
36.7
nM
|
|
|
Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
|
Homo sapiens
|
55.0
nM
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
105.21
%
|
|
|
Inhibition of mTORC1 (unknown origin)
|
Homo sapiens
|
0.8
nM
|
|
|
Inhibition of mTORC2 (unknown origin)
|
Homo sapiens
|
2.8
nM
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
118.71
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
107.55
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
10.89
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
5.91
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
10.89
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
5.91
%
|
|
