EcoDrugPlus


Synonyms	AZ-12600000 AZD 8055 AZD8055 Azd-8055
Status
Molecule Category	Free-form
UNII	970JJ37FPW
EPA CompTox	DTXSID001020704

Datasets:

Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	KVLFRAWTRWDEDF-IRXDYDNUSA-N
Smiles	COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO
InChI	InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H31N5O4
Molecular Weight	465.55
AlogP	2.64
Hydrogen Bond Acceptor	9.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	93.07
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	34.0

Mechanism of Action	Action	Reference
Serine/threonine-protein kinase mTOR inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family Atypical protein kinase FRAP subfamily	-	0.13-27	-	-	-
Enzyme Transferase	-	-	-	-	12-70
Enzyme	-	0.13-27	-	-	12-70
Other cytosolic protein	-	2.8	-	-	-
Unclassified protein	-	0.8-27	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	0.7-0.7	0.13-190	-	-	12-70

Target Conservation


Protein: Serine/threonine-protein kinase mTOR Description: Serine/threonine-protein kinase mTOR Organism : Homo sapiens P42345 ENSG00000198793

Cross References

Resources	Reference
CAS NUMBER	1009298-09-2
ChEBI	91329
ChEMBL	CHEMBL1801204
DrugBank	DB12774
FDA SRS	970JJ37FPW
Guide to Pharmacology	7714
PubChem	25262965
SureChEMBL	SCHEMBL298416
ZINC	ZINC000052509466

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 27^th July 2026

AZD-8055

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References