RILEMATOVIR

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Search structure


Synonyms	Jnj-53718678 Rilematovir
Status
Molecule Category	Free-form
UNII	NQ99E8OH3P

Structure


InChI Key	GTQTUABHRCWVLL-UHFFFAOYSA-N
Smiles	CS(=O)(=O)CCCn1c(Cn2c(=O)n(CC(F)(F)F)c3ccncc32)cc2cc(Cl)ccc21
InChI	InChI=1S/C21H20ClF3N4O3S/c1-33(31,32)8-2-7-27-16(10-14-9-15(22)3-4-17(14)27)12-28-19-11-26-6-5-18(19)29(20(28)30)13-21(23,24)25/h3-6,9-11H,2,7-8,12-13H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H20ClF3N4O3S
Molecular Weight	500.93
AlogP	3.85
Hydrogen Bond Acceptor	7.0
Number of Rotational Bond	7.0
Polar Surface Area	78.89
Molecular species	NEUTRAL
Aromatic Rings	4.0
Heavy Atoms	33.0

Pharmacology

Mechanism of Action	Action	Reference
Fusion glycoprotein F0 inhibitor	INHIBITOR	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Surface antigen	0.5012	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Human respiratory syncytial virus	0.2	-	-	-	-
Human respiratory syncytial virus B	0.2	-	-	-	-
Respiratory syncytial virus	0.46-0.5012	-	-	-	-

Cross References

Resources	Reference
CAS NUMBER	1383450-81-4
ChEMBL	CHEMBL4437054
FDA SRS	NQ99E8OH3P
PDB	6YA
PubChem	118892432
SureChEMBL	SCHEMBL17529353

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 23^rd March 2026