EcoDrugPlus


Synonyms	1589 RB 1589-RB EU-5306 Pefloxacin
Status
Molecule Category	Free-form
ATC	J01MA03
UNII	2H52Z9F2Q5
EPA CompTox	DTXSID3048493


InChI Key	FHFYDNQZQSQIAI-UHFFFAOYSA-N
Smiles	CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCN(C)CC3)cc21
InChI	InChI=1S/C17H20FN3O3/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21/h8-10H,3-7H2,1-2H3,(H,23,24)

Property Name	Value
Molecular Formula	C17H20FN3O3
Molecular Weight	333.36
AlogP	1.61
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	65.78
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	24.0

Mechanism of Action	Action	Reference
Bacterial DNA gyrase inhibitor	INHIBITOR	Other PubMed

Resources	Reference
ChEBI	50199
ChEMBL	CHEMBL267648
DrugBank	DB00487
DrugCentral	2071
FDA SRS	2H52Z9F2Q5
Human Metabolome Database	HMDB0014630
PharmGKB	PA164742856
PubChem	51081
SureChEMBL	SCHEMBL34292
ZINC	ZINC000000001894

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

PEFLOXACIN

Structure

Physicochemical Descriptors

Pharmacology

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