METFORMIN

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
ATC A10BA02
UNII 9100L32L2N
EPA CompTox DTXSID2023270

Structure

InChI Key XZWYZXLIPXDOLR-UHFFFAOYSA-N
Smiles CN(C)C(=N)NC(=N)N
InChI
InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)

Physicochemical Descriptors

Property Name Value
Molecular Formula C4H11N5
Molecular Weight 129.17
AlogP -1.03
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 4.0
Polar Surface Area 88.99
Molecular species BASE
Aromatic Rings 0.0
Heavy Atoms 9.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Phosphatase Protein Phosphatase Tyrosine protein phosphatase
- - - - 30.2-30.2
Enzyme Protease Serine protease Serine protease SC clan Serine protease S9B subfamily
- - - - 12.7-21.9
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - -4.5-19.6
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- - - - 11.1-19.6
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
270 9.9-189 - - -4.5-67.6
Mus musculus
- - - - 6-43
Rattus norvegicus
- - - - 7.86-75

Environmental Exposure

Environmental Exposure Map
Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia
USA
Vietnam

Cross References

Resources Reference
ChEBI 6801
ChEMBL CHEMBL1431
DrugBank DB00331
DrugCentral 1725
FDA SRS 9100L32L2N
Human Metabolome Database HMDB0001921
Guide to Pharmacology 4779
KEGG C07151
PDB MF8
PharmGKB PA450395
PubChem 4091
SureChEMBL SCHEMBL8944
ZINC ZINC000012859773
CONTENTS