PF-06651600

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Synonyms
Status
Molecule Category Free-form
UNII 2OYE00PC25

Structure

InChI Key CBRJPFGIXUFMTM-WDEREUQCSA-N
Smiles C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C
InChI
InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H19N5O
Molecular Weight 285.35
AlogP 1.94
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 73.91
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Mechanism of Action Action Reference
TEC family kinase inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakA family
- 0.3-202 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakB family
- 0.3-202 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Tec family
- 193-607 - 26.9-679 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 0.3-607 - 26.9-679 -

Related Entries

Cross References

Resources Reference
ChEMBL CHEMBL4085457
DrugBank DB14924
FDA SRS 2OYE00PC25
Guide to Pharmacology 9559
SureChEMBL SCHEMBL16764638
ZINC ZINC000526061581
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