PAZOPANIB

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
ATC L01EX03
UNII 7RN5DR86CK
EPA CompTox DTXSID8048733

Structure

InChI Key CUIHSIWYWATEQL-UHFFFAOYSA-N
Smiles Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O
InChI
InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H23N7O2S
Molecular Weight 437.53
AlogP 3.14
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 119.03
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 31.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 930 - - -
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase RIO family Atypical protein kinase RIO2 subfamily
- - 610 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family
- - 750-750 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase NAK family
- - 200-360 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase NEK family
- - 980-980 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase PLK family
- - 290-290 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase TTK family
- - 150-150 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase ULK family
- - 470-470 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE11 family STE protein kinase MEKK2
- - 290 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE11 family
- - 290 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase KHS subfamily
- - 750-750 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase MSN subfamily
- - 310-310 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase SLK subfamily
- - 84-240 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase TAO subfamily
- - 45-240 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE7 family
- - 480-590 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family
- - 380-800 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ack family
- - 980 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase DDR family
- 50-51 57-581 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family
- 140-163 210-990 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- 71-274 1.8-810 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ret family
- - 270-310 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Sev family
- - 920-920 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
- - 750-890 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Tie family
- - 700-700 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 5.012-98 14-27 - 95
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase IRAK family
- - 800-800 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase LISK family TKL protein kinase LIMK subfamily
- - 390-720 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase MLK family TKL protein kinase MLK subfamily
- - 290-740 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase RAF family
- - 430-900 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase RIPK family
- 873 260-580 - -
Enzyme Kinase Protein Kinase
- 5.012-98 1.8-810 - 95
Enzyme Lyase
- - - 9.1 -
Enzyme Transferase
- - 280-960 - -
Membrane receptor
- - 81 - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 5.012-930 2-990 9.1 16-110
Mus musculus
- - - - 0-93

Cross References

Resources Reference
ChEBI 71219
ChEMBL CHEMBL477772
DrugBank DB06589
DrugCentral 4118
FDA SRS 7RN5DR86CK
Guide to Pharmacology 5698
PubChem 10113978
SureChEMBL SCHEMBL588608
ZINC ZINC000011617039
CONTENTS