EcoDrugPlus


Synonyms	Hydrocodone
Status
Molecule Category	Free-form
ATC	R05DA03
UNII	6YKS4Y3WQ7
EPA CompTox	DTXSID8023131


InChI Key	LLPOLZWFYMWNKH-CMKMFDCUSA-N
Smiles	COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
InChI	InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1

Property Name	Value
Molecular Formula	C18H21NO3
Molecular Weight	299.37
AlogP	1.93
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	1.0
Polar Surface Area	38.77
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	22.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Opioid receptor	-	-	-	9.5-260	37

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	9.5-260	37

Countries
USA

Resources	Reference
ChEBI	5779
ChEMBL	CHEMBL1457
DrugBank	DB00956
DrugCentral	1386
FDA SRS	6YKS4Y3WQ7
Human Metabolome Database	HMDB0015091
Guide to Pharmacology	7081
KEGG	C08024
PharmGKB	PA449900
PubChem	5284569
SureChEMBL	SCHEMBL2987
ZINC	ZINC000001280665

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

HYDROCODONE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Environmental Exposure

Cross References