EcoDrugPlus


Synonyms	Ambien Sanval Zolpidem Zolpidem civ
Status
Molecule Category	Free-form
ATC	N05CF02
UNII	7K383OQI23
EPA CompTox	DTXSID7045946


InChI Key	ZAFYATHCZYHLPB-UHFFFAOYSA-N
Smiles	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1
InChI	InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3

Property Name	Value
Molecular Formula	C19H21N3O
Molecular Weight	307.4
AlogP	3.25
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	3.0
Polar Surface Area	37.61
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	23.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel GABA-A receptor	180-737	14-130	-	19-980	35-35
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	78.05-177.44

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bos taurus	-	-	-	51	-
Cricetulus griseus	-	-	-	-	78.05-177.44
Homo sapiens	180-240	-	-	20-400	-
Rattus norvegicus	191-341	48	-	19-980	35-220
Xenopus laevis	198-737	-	-	-	-

Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia

Resources	Reference
ChEBI	10125
ChEMBL	CHEMBL911
DrugBank	DB00425
DrugCentral	2870
FDA SRS	7K383OQI23
Human Metabolome Database	HMDB0005023
Guide to Pharmacology	4362
KEGG	C07219
PharmGKB	PA451976
PubChem	5732
SureChEMBL	SCHEMBL80516
ZINC	ZINC000000003876

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

ZOLPIDEM

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Environmental Exposure

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