VOGLIBOSE

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
ATC A10BF03
UNII S77P977AG8
EPA CompTox DTXSID2021442

Structure

InChI Key FZNCGRZWXLXZSZ-CIQUZCHMSA-N
Smiles OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O
InChI
InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H21NO7
Molecular Weight 267.28
AlogP -4.49
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 8.0
Number of Rotational Bond 5.0
Polar Surface Area 153.64
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 18.0

Pharmacology

Mechanism of Action Action Reference
Alpha glucosidase inhibitor INHIBITOR PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 70-200 - - -
Enzyme
- 70-370 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 70 - - -
Rattus norvegicus
- 70-370 - - 103.95

Target Conservation

Protein: Alpha glucosidase
Description: Maltase-glucoamylase
Organism : Homo sapiens
O43451 ENSG00000257335
Protein: Alpha glucosidase
Description: Lysosomal alpha-glucosidase
Organism : Homo sapiens
P10253 ENSG00000171298
Protein: Alpha glucosidase
Description: Sucrase-isomaltase, intestinal
Organism : Homo sapiens
P14410 ENSG00000090402
Protein: Alpha glucosidase
Description: Probable maltase-glucoamylase 2
Organism : Homo sapiens
Q2M2H8 ENSG00000257743

Related Entries

Cross References

Resources Reference
ChEBI 32300
ChEMBL CHEMBL476960
DrugBank DB04878
DrugCentral 2845
FDA SRS S77P977AG8
Human Metabolome Database HMDB0015598
PDB VOG
PharmGKB PA164752433
PubChem 444020
SureChEMBL SCHEMBL5882
ZINC ZINC000003788703
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