VATALANIB


Synonyms	BAY-86-5127 CGP-79787 K-222584 NVP-PTK787 PTK-787 PTK787 Ptk-787 Vatalanib Vatalanib succinate ZK-222584 ZK222584
Status
Molecule Category	Free-form
UNII	5DX9U76296
EPA CompTox	DTXSID2046919


InChI Key	YCOYDOIWSSHVCK-UHFFFAOYSA-N
Smiles	Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
InChI	InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)

Mechanism of Action	Action	Reference
Macrophage colony stimulating factor receptor inhibitor	INHIBITOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family Atypical protein kinase FRAP subfamily	-	-	-	-	49
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family	-	-	-	-	25
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase DDR family	-	-	270-270	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family	-	457.7	-	-	46-67
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	-	-	-	31
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	490-730	5.1-700	-	72
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family	-	-	-	-	16
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	10-380	9.6-330	-	58

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Danio rerio	-	230	-	-	-
Homo sapiens	-	10-457.7	5.1-700	-	16-72
Rattus norvegicus	-	-	-	-	23


Protein: Macrophage colony stimulating factor receptor Description: Macrophage colony-stimulating factor 1 receptor Organism : Homo sapiens P07333 ENSG00000182578












Protein: Platelet-derived growth factor receptor Description: Platelet-derived growth factor receptor beta Organism : Homo sapiens P09619 ENSG00000113721











Protein: Stem cell growth factor receptor Description: Mast/stem cell growth factor receptor Kit Organism : Homo sapiens P10721 ENSG00000157404












Protein: Platelet-derived growth factor receptor Description: Platelet-derived growth factor receptor alpha Organism : Homo sapiens P16234 ENSG00000134853












Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 1 Organism : Homo sapiens P17948 ENSG00000102755











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 3 Organism : Homo sapiens P35916 ENSG00000037280











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 2 Organism : Homo sapiens P35968 ENSG00000128052

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