EcoDrugPlus


Synonyms	FEMA NO. 3736 L-tyrosine Levodopa impurity, l-tyrosine- Levodopa related compound l-tyrosine NSC-82624 Tyrosine
Status
Molecule Category	Free-form
UNII	42HK56048U
EPA CompTox	DTXSID1023730


InChI Key	OUYCCCASQSFEME-QMMMGPOBSA-N
Smiles	N[C@@H](Cc1ccc(O)cc1)C(=O)O
InChI	InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

Property Name	Value
Molecular Formula	C9H11NO3
Molecular Weight	181.19
AlogP	0.35
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	3.0
Polar Surface Area	83.55
Molecular species	ZWITTERION
Aromatic Rings	1.0
Heavy Atoms	13.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC03 and SLC07 families of heteromeric amino acid transporters (HATs) SLC07 Cationic amino acid transporter/glycoprotein-associated family	-	-	-	-	68-68

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	68-68
Mycobacterium tuberculosis	-	-	-	-	41

Resources	Reference
ChEBI	58315
ChEMBL	CHEMBL925
DrugBank	DB00135
DrugCentral	2786
FDA SRS	42HK56048U
Human Metabolome Database	HMDB0000158
Guide to Pharmacology	4791
KEGG	C00082
PDB	TYR
PharmGKB	PA451822
PubChem	6057
SureChEMBL	SCHEMBL1581
ZINC	ZINC000000266964

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

TYROSINE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References