EcoDrugPlus


Synonyms	Amylozine Apo-trifluoperazine Flurazine NSC-17474 NSC-46061 RP-7623 Stelazine Stelazine fte Trifluoperazine
Status
Molecule Category	Free-form
ATC	N05AB06
UNII	214IZI85K3
EPA CompTox	DTXSID1046928


InChI Key	ZEWQUBUPAILYHI-UHFFFAOYSA-N
Smiles	CN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChI	InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3

Property Name	Value
Molecular Formula	C21H24F3N3S
Molecular Weight	407.51
AlogP	4.95
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	4.0
Polar Surface Area	9.72
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	28.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Isomerase	-	-	-	8-500	-
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	79.8
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	350	-	29.3	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	16	0.5322	2.2	73-81
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	-	1.043	5.2-411	-
Membrane receptor	-	16	0.5322	5.2-411	73-81
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4	-	-	-	-	2.8
Unclassified protein	-	700	-	3.9	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	15	79.8
Hepatitis C virus	-	700	-	-	-
Homo sapiens	-	-	500-800	3.9-24.2	63.8-81
Rattus norvegicus	-	-	392	411	1.7-83.3
Saccharomyces cerevisiae	-	-	-	500	-

Resources	Reference
ChEBI	45951
ChEMBL	CHEMBL422
DrugBank	DB00831
DrugCentral	2740
FDA SRS	214IZI85K3
Human Metabolome Database	HMDB0014969
Guide to Pharmacology	214
KEGG	C07168
PDB	TFP
PharmGKB	PA451771
PubChem	5566
SureChEMBL	SCHEMBL24866
ZINC	ZINC000019418959

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

TRIFLUOPERAZINE

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Physicochemical Descriptors

Pharmacology

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