SULPIRIDE

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Synonyms
Status
Molecule Category Free-form
ATC N05AL01
UNII 7MNE9M8287
EPA CompTox DTXSID1042574

Structure

InChI Key BGRJTUBHPOOWDU-UHFFFAOYSA-N
Smiles CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)ccc1OC
InChI
InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H23N3O4S
Molecular Weight 341.43
AlogP 0.56
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 101.73
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 23.0

Pharmacology

Mechanism of Action Action Reference
Dopamine D2 receptor antagonist ANTAGONIST PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Lyase
- 40-620 - 0.8-873 -
Enzyme
- 40-620 - 0.8-873 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 10.28-560 1.5-39.81 5.51-240 87.9-92.2
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 106.19-121.78
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Anopheles gambiae
- - - 29.5 -
Astrosclera willeyana
- - - 378 -
Brucella suis
- - - 19-84 -
Candida albicans
- - - 760-760 -
Candida glabrata
- - - 113 -
Chionodraco hamatus
- - - 511 -
Colwellia psychrerythraea
- - - 505 -
Cricetulus griseus
- - - - 106.19-121.78
Cryptococcus neoformans
- - - 812-812 -
Enterobacter sp.
- - - 132 -
Helicobacter pylori
- - - 35-204 -
Homo sapiens
- 10.28-560 2.818-39.81 0.8-174 87.9-92.2
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
- - - 245-253 -
Malassezia globosa CBS 7966
- - - 320 -
Mus musculus
- - - 73 -
Mycobacterium tuberculosis
- - - 266 -
Nostoc commune
- - - 60.5-60.5 -
Porphyromonas gingivalis
- - - 418-418 -
Saccharomyces cerevisiae
- - - 124 -
Stylophora pistillata
- - - 415-430 -
Sulfurihydrogenibium yellowstonense
- - - 67.4-67.4 -
Thalassiosira weissflogii
- - - 259 -
Thiomicrospira crunogena XCL-2
- - - 873 -
Trypanosoma cruzi
- - - 87.9 -
Vibrio cholerae
- - - 68-77.9 -

Target Conservation

Protein: Dopamine D2 receptor
Description: D(2) dopamine receptor
Organism : Homo sapiens
P14416 ENSG00000149295

Related Entries

Environmental Exposure

Environmental Exposure Map
Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia
Vietnam

Cross References

Resources Reference
ChEBI 32168
ChEMBL CHEMBL26
DrugBank DB00391
DrugCentral 2537
FDA SRS 7MNE9M8287
Human Metabolome Database HMDB0014535
Guide to Pharmacology 5501
PharmGKB PA164745485
PubChem 5355
SureChEMBL SCHEMBL8421
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