RILMENIDINE

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Synonyms
Status
Molecule Category Free-form
ATC C02AC06
UNII P67IM25ID8
EPA CompTox DTXSID3045194

Structure

InChI Key CQXADFVORZEARL-UHFFFAOYSA-N
Smiles C1COC(NC(C2CC2)C2CC2)=N1
InChI
InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H16N2O
Molecular Weight 180.25
AlogP 1.15
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 33.62
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 13.0

Pharmacology

Mechanism of Action Action Reference
Nischarin agonist AGONIST PubMed PubMed Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
177.83-724.44 - - 12.59-300 -
Other cytosolic protein
- - - 11.22-83.1 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Bos taurus
- - - 56.23-74.13 -
Homo sapiens
177.83 - - 12.59-300 -
Rattus norvegicus
- - - 11.22-83.1 -

Target Conservation

Protein: Nischarin
Description: Nischarin
Organism : Homo sapiens
Q9Y2I1 ENSG00000010322

Cross References

Resources Reference
ChEBI 8862
ChEMBL CHEMBL289480
DrugBank DB11738
DrugCentral 2381
FDA SRS P67IM25ID8
KEGG C11120
PubChem 68712
SureChEMBL SCHEMBL114420
ZINC ZINC000000009708
CONTENTS