RGB-286638


InChI Key	XLSYZSRXVVCHLS-UHFFFAOYSA-N
Smiles	COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1
InChI	InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)

Mechanism of Action	Action	Reference
Cyclin-dependent kinase 1 inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDC2 subfamily	-	2-2	-	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK5 subfamily	-	2	-	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK7 subfamily	-	2	-	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK9 subfamily	-	1	-	-	-
Enzyme Kinase Protein Kinase CMGC protein kinase group	-	2-2	-	-	-
Enzyme Kinase Protein kinase regulatory subunit	-	2	-	-	-
Other cytosolic protein	-	1-2	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	1-2	-	-	-


Protein: Cyclin-dependent kinase 1 Description: Cyclin-dependent kinase 1 Organism : Homo sapiens P06493 ENSG00000170312














Protein: Cyclin-dependent kinase 4 Description: Cyclin-dependent kinase 4 Organism : Homo sapiens P11802 ENSG00000135446












Protein: Cyclin-dependent kinase 2 Description: Cyclin-dependent kinase 2 Organism : Homo sapiens P24941 ENSG00000123374












Protein: Cyclin-dependent kinase 7 Description: Cyclin-dependent kinase 7 Organism : Homo sapiens P50613 ENSG00000134058














Protein: Cyclin-dependent kinase 9 Description: Cyclin-dependent kinase 9 Organism : Homo sapiens P50750 ENSG00000136807














Protein: Cyclin-dependent kinase 5 Description: Cyclin-dependent kinase 5 Organism : Homo sapiens Q00535 ENSG00000164885

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